Protein Info for CA265_RS01860 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: type I glyceraldehyde-3-phosphate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00044: Gp_dh_N
  • amino acids 1 to 99 (99 residues), 115 bits, E=1.8e-37
• TIGR01534: glyceraldehyde-3-phosphate dehydrogenase, type I
  • amino acids 2 to 320 (319 residues), 398.3 bits, E=1.4e-123
• PF02800: Gp_dh_C
  • amino acids 153 to 308 (156 residues), 201 bits, E=8.9e-64

Best Hits

Swiss-Prot: 52% identical to G3P_AQUAE: Glyceraldehyde-3-phosphate dehydrogenase (gap) from Aquifex aeolicus (strain VF5)

KEGG orthology group: K00134, glyceraldehyde 3-phosphate dehydrogenase [EC: 1.2.1.12] (inferred from 72% identity to phe:Phep_3337)

MetaCyc: 50% identical to Gap (Thermotoga maritima)
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). [EC: 1.2.1.12]

Predicted SEED Role

"NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)" in subsystem Calvin-Benson cycle or Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Pyridoxin (Vitamin B6) Biosynthesis or Redox-dependent regulation of nucleus processes (EC 1.2.1.12)

MetaCyc Pathways

• superpathway of glucose and xylose degradation (16/17 steps found)
• gluconeogenesis I (12/13 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (21/26 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (18/22 steps found)
• glycolysis II (from fructose 6-phosphate) (10/11 steps found)
• glycolysis III (from glucose) (10/11 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (14/17 steps found)
• glycolysis I (from glucose 6-phosphate) (11/13 steps found)
• formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
• homolactic fermentation (10/12 steps found)
• Bifidobacterium shunt (12/15 steps found)
• pyridoxal 5'-phosphate biosynthesis I (6/7 steps found)
• glycolysis IV (8/10 steps found)
• Entner-Doudoroff pathway I (7/9 steps found)
• gluconeogenesis III (9/12 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• superpathway of N-acetylneuraminate degradation (16/22 steps found)
• heterolactic fermentation (13/18 steps found)
• sucrose biosynthesis I (from photosynthesis) (6/9 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (13/19 steps found)
• glycolysis VI (from fructose) (7/11 steps found)
• superpathway of hexitol degradation (bacteria) (12/18 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (7/12 steps found)
• glycerol degradation to butanol (9/16 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Glycolysis / Gluconeogenesis

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.12

Use Curated BLAST to search for 1.2.1.12

Sequence Analysis Tools

See A0A1X9Z0L3 at UniProt or InterPro

Protein Sequence (328 amino acids)

>CA265_RS01860 type I glyceraldehyde-3-phosphate dehydrogenase (Pedobacter sp. GW460-11-11-14-LB5)
MRLAINGFGRIGRTFLRLALAEGFEVVAINDLAEAKTMAHLFKYDTVHGVFAGNVSAKPD
ALVINQLSIPVFAIKDADELPWSALRVDLVIDCTGKNLTKSLAEKHITSGAKQVLISAPA
AEDIPMVVLGVNDHQIDLTSAVLSNASCTTNNIAPMIKILNDNWGVEEGYITTIHSMTGD
QNLHDANHKDLRRARAASSSIIPTTTGAAKAITHIFPELDGRLGGAGIRVPVLNGSLTDF
TCLLKKKTTIEEINAAFKHAAENELKGLLEYTEDPIVSVDIIDNPHSCIFDSLLTSIVGD
LVKVVGWYDNEFGYSSRLIDVVKKIDRL