Protein Info for BWI76_RS24630 in Klebsiella michiganensis M5al

Annotation: putrescine aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03372: putrescine aminotransferase
  • amino acids 17 to 458 (442 residues), 951.3 bits, E=3.4e-291
• PF00202: Aminotran_3
  • amino acids 83 to 453 (371 residues), 342.1 bits, E=1.9e-106

Best Hits

Swiss-Prot: 97% identical to PAT_KLEP3: Putrescine aminotransferase (patA) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K09251, putrescine aminotransferase [EC: 2.6.1.82] (inferred from 97% identity to kpu:KP1_4798)

MetaCyc: 94% identical to putrescine aminotransferase (Escherichia coli K-12 substr. MG1655)
Putrescine aminotransferase. [EC: 2.6.1.82]; 2.6.1.82 [EC: 2.6.1.82]; Diamine transaminase. [EC: 2.6.1.82, 2.6.1.29]

Predicted SEED Role

"Putrescine aminotransferase (EC 2.6.1.82)" in subsystem Arginine and Ornithine Degradation (EC 2.6.1.82)

MetaCyc Pathways

• superpathway of L-arginine and L-ornithine degradation (13/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (11/11 steps found)
• superpathway of ornithine degradation (8/8 steps found)
• L-lysine degradation X (5/6 steps found)
• putrescine degradation I (2/2 steps found)
• L-lysine degradation I (5/7 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.29 or 2.6.1.82

Sequence Analysis Tools

See A0A285B9P5 at UniProt or InterPro

Protein Sequence (468 amino acids)

>BWI76_RS24630 putrescine aminotransferase (Klebsiella michiganensis M5al)
MIRPAQEHILNRLPSSASALACSAHALNLIEKRTLDHEEMKSLNQEVREYFKEHVNPGFL
AYRKSVTAGGDYGAVEWQAGGLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVENQL
AKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFSNSGTESVEAALKLAKAYQSPRGKF
TFVATSGAFHGKSLGALSATAKSTFRKPFMPLLPGFRHVPFGDINAMRTLLSECKKTGDD
VAAVILEPIQGEGGVILPPPGYLPAVRKLCDEFGALLILDEVQTGMGRTGKMFACEHENV
QPDILCLAKALGGGVMPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLL
TQNLPAQAEQKGDMLLDGFRQLAREYPDLVNEVRGKGMLMAIEFVDNEIGYDFASEMFRQ
RVLVAGTLNNARTIRVEPPLTLTLEQCEQVLKAARLALAALRVSVEEA