Protein Info for BWI76_RS23725 in Klebsiella michiganensis M5al

Updated annotation (from data): 2-deoxy-D-ribonate transporter 2
Rationale: Important in carbon source 2-Deoxy-D-ribonic acid lithium salt. Similar to deoxyribonate transporters in other bacteria. However it is not clear why this organism has two deoxyribonate transporters (this gene and BWI76_RS23715)
Original annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 transmembrane" amino acids 21 to 39 (19 residues), see Phobius details amino acids 62 to 83 (22 residues), see Phobius details amino acids 98 to 126 (29 residues), see Phobius details amino acids 163 to 183 (21 residues), see Phobius details amino acids 188 to 208 (21 residues), see Phobius details amino acids 258 to 274 (17 residues), see Phobius details amino acids 287 to 310 (24 residues), see Phobius details amino acids 322 to 340 (19 residues), see Phobius details amino acids 346 to 367 (22 residues), see Phobius details amino acids 379 to 403 (25 residues), see Phobius details amino acids 415 to 435 (21 residues), see Phobius details PF07690: MFS_1" amino acids 31 to 293 (263 residues), 91.7 bits, see alignment E=7e-30 amino acids 263 to 441 (179 residues), 85.1 bits, see alignment E=7.1e-28 PF00083: Sugar_tr" amino acids 59 to 430 (372 residues), 51.5 bits, see alignment E=1.2e-17 PF13347: MFS_2" amino acids 160 to 417 (258 residues), 44.6 bits, see alignment E=1.2e-15

Best Hits

KEGG orthology group: None (inferred from 98% identity to kpn:KPN_01690)

Predicted SEED Role

"Permeases of the major facilitator superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B9G8 at UniProt or InterPro

Protein Sequence (445 amino acids)

>BWI76_RS23725 2-deoxy-D-ribonate transporter 2 (Klebsiella michiganensis M5al)
MTTINQTPAGEQGAKKRLIHRFSWVSLLVCWLIWVLNAYDREMILRLGPVISKEFSLSPE
QWGNVVALIMVALAVLDIPGSIWSDRYGSGWKRARFQVPLVLGYTALSFISGIKAISHGL
TAFVLLRVGVNLGAGWGEPVGVSNTAEWWPKEKRGFALGVHHTGYPIGALLSGVVASLVL
SAFGEGSWRYCFLLALIVAIPLMIFWAKYSTADRINTLYQHIDSQGMTRPATQESSHVAK
GEGMKTFLRTLRNRNISLTAGNTLLTQIVYMGINVVLPPYLYHVSGLSLAASAGLSIIFT
LTGTLGQIIWPWLSDSFGRKRTLIVCGLWMSIGIALFYFATNMPRLIAIQLFFGLVANAV
WPIYYAMASDSAEERATSTANGIITTAMFIGGGLSPLLMGWLIQFGGGWENPAGYIYAFF
TMAGCALLGMLLQLMTTDKTPRKAH