Protein Info for BWI76_RS23290 in Klebsiella michiganensis M5al

Annotation: DNA mismatch repair protein MutH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 230 TIGR02248: DNA mismatch repair endonuclease MutH" amino acids 10 to 226 (217 residues), 377.8 bits, see alignment E=5.6e-118 PF02976: MutH" amino acids 59 to 157 (99 residues), 125.7 bits, see alignment E=3.3e-41

Best Hits

Swiss-Prot: 93% identical to MUTH_KLEP7: DNA mismatch repair protein MutH (mutH) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K03573, DNA mismatch repair protein MutH (inferred from 93% identity to kpe:KPK_0874)

MetaCyc: 86% identical to DNA mismatch repair protein MutH (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"DNA mismatch repair endonuclease MutH" in subsystem DNA repair, bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B7S3 at UniProt or InterPro

Protein Sequence (230 amino acids)

>BWI76_RS23290 DNA mismatch repair protein MutH (Klebsiella michiganensis M5al)
MPTIAPLLSPPQSQEQLLAQAQQLAGYSLGELAQLAGIPIPRDLKRDKGWIGILLEIWLG
ASAGSKPEQDFAALGVELKTIPIDSSGRPLETTFVCVAPLTGNSGVTWESSHVRHKLKRV
LWVPVEGERTIPLADRRVGAPLLWSPSEEEDRQLRMDWEELMDLIVLGQVERITARHGEV
LQLRPKAANSKALTEAVGARGEPILTLPRGFYLKKNFTAALLARHFLLSS