Protein Info for BWI76_RS22920 in Klebsiella michiganensis M5al

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 436 transmembrane" amino acids 21 to 39 (19 residues), see Phobius details amino acids 59 to 81 (23 residues), see Phobius details amino acids 90 to 109 (20 residues), see Phobius details amino acids 115 to 137 (23 residues), see Phobius details amino acids 156 to 177 (22 residues), see Phobius details amino acids 208 to 226 (19 residues), see Phobius details amino acids 260 to 281 (22 residues), see Phobius details amino acids 295 to 316 (22 residues), see Phobius details amino acids 325 to 343 (19 residues), see Phobius details amino acids 349 to 371 (23 residues), see Phobius details amino acids 383 to 402 (20 residues), see Phobius details amino acids 409 to 429 (21 residues), see Phobius details TIGR00885: L-fucose:H+ symporter permease" amino acids 22 to 430 (409 residues), 659.7 bits, see alignment E=1.1e-202 PF07690: MFS_1" amino acids 30 to 391 (362 residues), 78.5 bits, see alignment E=2.4e-26

Best Hits

Swiss-Prot: 93% identical to FUCP_ECOLI: L-fucose-proton symporter (fucP) from Escherichia coli (strain K12)

KEGG orthology group: K02429, MFS transporter, FHS family, L-fucose permease (inferred from 97% identity to cko:CKO_04160)

MetaCyc: 93% identical to L-fucose:H+ symporter (Escherichia coli K-12 substr. MG1655)
RXN0-7221; RXN0-7222; TRANS-RXN-20

Predicted SEED Role

"Fucose permease" in subsystem L-fucose utilization or L-fucose utilization temp

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AXQ9 at UniProt or InterPro

Protein Sequence (436 amino acids)

>BWI76_RS22920 MFS transporter (Klebsiella michiganensis M5al)
MGNTTIQTQSFRAVETGKSKRYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQ
AGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFWPAAEVMNYTLFLI
GLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVP
HQSQDVLDKMAPEQLSAYKHSLVLSVQTPYMIIVAVVLLVALLIMLTKFPALQSDDHSDA
TQSSFSASLARLVRVRHWRWAVLAQFCYVGAQTACWSYLIRYAIEEIPGMTPGFAANYLT
GTMVCFFIGRFSGTWLISRFAPHKVLAAYALLSMILCLISAFTGGHVGLLALTLCSAFMS
IQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGNIPTAELVPALCF
AVIFIFARFRSQTAAN