Protein Info for BWI76_RS21845 in Klebsiella michiganensis M5al

Annotation: short-chain dehydrogenase/reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 277 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF00106: adh_short" amino acids 5 to 188 (184 residues), 164.8 bits, see alignment E=3.6e-52 PF08659: KR" amino acids 6 to 165 (160 residues), 33.2 bits, see alignment E=1e-11 PF01370: Epimerase" amino acids 7 to 120 (114 residues), 25.1 bits, see alignment E=2.3e-09 PF13561: adh_short_C2" amino acids 11 to 188 (178 residues), 128.5 bits, see alignment E=6.4e-41

Best Hits

KEGG orthology group: None (inferred from 100% identity to kpe:KPK_B0004)

Predicted SEED Role

"Short-chain dehydrogenase/reductase SDR"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (277 amino acids)

>BWI76_RS21845 short-chain dehydrogenase/reductase (Klebsiella michiganensis M5al)
MTSAKTILITGVSSGFGRALAQEALATGHRVIGTVRSREAQHDFEALHSQRAFGRLLDIT
DFEHIDEVVAEIESTVGPVDVLVNNAGYGHEGIMEESSLAEMRRQFEVNVFGAVAMIKAM
LPGMRQRRHGHIINITSMGSFITLPGISYYCGSKFALEGISETLSKELAPFNIHVTAVAP
GSFRTDWAGRSMVRSARSIPDYDALFDPIRQAREEKSGKQLGDPVKAAHAMLAMIESQNP
PTHLLLGSDALSLVRQKLEALGKEIEQWEEITRSTDG