Protein Info for BWI76_RS21145 in Klebsiella michiganensis M5al

Annotation: co-chaperone HscB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 171 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details TIGR00714: Fe-S protein assembly co-chaperone HscB" amino acids 13 to 168 (156 residues), 211.1 bits, see alignment E=4.7e-67 PF07743: HSCB_C" amino acids 88 to 161 (74 residues), 66.7 bits, see alignment E=1.9e-22

Best Hits

Swiss-Prot: 93% identical to HSCB_KLEP3: Co-chaperone protein HscB (hscB) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K04082, molecular chaperone HscB (inferred from 92% identity to kva:Kvar_1200)

MetaCyc: 90% identical to [Fe-S] cluster biosynthesis co-chaperone HscB (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Chaperone protein HscB" in subsystem Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B7T1 at UniProt or InterPro

Protein Sequence (171 amino acids)

>BWI76_RS21145 co-chaperone HscB (Klebsiella michiganensis M5al)
MDYFTLFGLPASYTLSLEPLAARYQELQRQYHPDKFASGSAAEQLAAVQQSATINQAWQT
LRHPLTRAEYLLSLHGFDLASEQHTVRDTAFLMEQLELREELDEIGKAKDEARLESFIKR
VKAQFDTRHQLMVEQLNNETWEAAADTVRKLRFLDKLRSSAEQLEEKLLDF