Protein Info for BWI76_RS20765 in Klebsiella michiganensis M5al

Annotation: ethanolamine ammonia lyase large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 453 PF06751: EutB" amino acids 12 to 444 (433 residues), 688.4 bits, see alignment E=2.1e-211

Best Hits

Swiss-Prot: 97% identical to EUTB_SALTY: Ethanolamine ammonia-lyase heavy chain (eutB) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03735, ethanolamine ammonia-lyase large subunit [EC: 4.3.1.7] (inferred from 99% identity to kpu:KP1_4034)

MetaCyc: 95% identical to ethanolamine ammonia-lyase subunit alpha (Escherichia coli K-12 substr. MG1655)
Ethanolamine ammonia-lyase. [EC: 4.3.1.7]

Predicted SEED Role

"Ethanolamine ammonia-lyase heavy chain (EC 4.3.1.7)" in subsystem Ethanolamine utilization (EC 4.3.1.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.3.1.7

Use Curated BLAST to search for 4.3.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B7E4 at UniProt or InterPro

Protein Sequence (453 amino acids)

>BWI76_RS20765 ethanolamine ammonia lyase large subunit (Klebsiella michiganensis M5al)
MKLKTTLFGNVYQFKDVKEVLAKANELRSGDVLAGVAAESSQQRVAAKQVLSDMTVADIR
NNPVIPYEEDCVTRLIQDDVNETAYQRIKNWTISDLREYVLNDEVTSDDIAFVRKGLTSE
VVAAVAKVCSNADLIYGAKKMPVIKKANTTIGLPGTFSCRLQPNDTRDDVQSIAAQIYEG
LSFGAGDAVIGVNPVTDDVENLTRVLDTVYGVIDKFNIPTQGCVLAHVTTQIEAIRRGAP
GGLIFQSICGSEKGLKEFGVELAMLDEARAVGAEFNRIAGENCLYFETGQGSALSAGANF
GADQVTMEARNYGLARHYDPFLVNTVVGFIGPEYLYNDRQIIRAGLEDHFMGKLSGISMG
CDCCYTNHADADQNLNENLMILLATAGCNYIMGMPLGDDIMLNYQTTAFHDTATVRQLLN
LRPSPEFERWLETMGIMANGRLTKRAGDPSLFF