Protein Info for BWI76_RS18335 in Klebsiella michiganensis M5al

Annotation: DNA-binding response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 218 PF00072: Response_reg" amino acids 4 to 116 (113 residues), 104.3 bits, see alignment E=6.5e-34 PF00196: GerE" amino acids 149 to 204 (56 residues), 73.5 bits, see alignment E=1.2e-24

Best Hits

Swiss-Prot: 94% identical to UVRY_ECOL6: Response regulator UvrY (uvrY) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K07689, two-component system, NarL family, invasion response regulator UvrY (inferred from 97% identity to kva:Kvar_1695)

Predicted SEED Role

"BarA-associated response regulator UvrY (= GacA = SirA)" in subsystem Pseudomonas quinolone signal PQS or Quorum sensing regulation in Pseudomonas or Type III secretion system orphans

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B5Z5 at UniProt or InterPro

Protein Sequence (218 amino acids)

>BWI76_RS18335 DNA-binding response regulator (Klebsiella michiganensis M5al)
MINVLLVDDHELVRAGIRRILEDIKGIKVAGEACCGEDAVKWCRANPVDVVLMDMNMPGI
GGLEATRKIARSVADAKVIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVNAIRCVAS
GQRYIASDIAQQMALSQIEPEKAESPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAESLASQ