Protein Info for BWI76_RS16705 in Klebsiella michiganensis M5al

Annotation: glucose dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 801 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 45 to 62 (18 residues), see Phobius details amino acids 68 to 85 (18 residues), see Phobius details amino acids 91 to 113 (23 residues), see Phobius details amino acids 124 to 145 (22 residues), see Phobius details TIGR03074: membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family" amino acids 25 to 800 (776 residues), 900 bits, see alignment E=5.5e-275 PF13360: PQQ_2" amino acids 216 to 393 (178 residues), 31.3 bits, see alignment E=2.5e-11 amino acids 677 to 767 (91 residues), 31.7 bits, see alignment E=1.9e-11 PF01011: PQQ" amino acids 227 to 254 (28 residues), 21.6 bits, see alignment (E = 2e-08) amino acids 447 to 473 (27 residues), 24.8 bits, see alignment (E = 2.1e-09) amino acids 730 to 764 (35 residues), 29.3 bits, see alignment (E = 7.6e-11)

Best Hits

KEGG orthology group: None (inferred from 90% identity to eae:EAE_17560)

Predicted SEED Role

"Quinate/shikimate dehydrogenase [Pyrroloquinoline-quinone] (EC 1.1.99.25)" in subsystem Chorismate Synthesis or Quinate degradation (EC 1.1.99.25)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.25

Use Curated BLAST to search for 1.1.99.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B522 at UniProt or InterPro

Protein Sequence (801 amino acids)

>BWI76_RS16705 glucose dehydrogenase (Klebsiella michiganensis M5al)
MDERQGSGRGVFFTVYRLLFVLLSFGIGLFFTLWGGKLLSLGGSAWYLLAGLAYLLIAVG
YLIRSRYVLPFAILTFLLTLCWALYEVQFSYWGLIPRLVVPALMLMLALWLAATLPMRPA
RRRYANWSASAIFLVLLATLVSAFYPHGAIHNGVVNASGDATPTLASKSDNWAFFGRDAS
GTRFAPYDEITPQNVKNLKVAWTYHTGRRLTGAGIGVDENTPLQIGDTLYSCTPLNVVTA
LDADTGKARWRFDPHAGTAEHVTCRGVGYYDVQSDDSLSAEEKASPALLQCPQRILVSTV
DARLIALNAKTGEPCDDFGDHGSVDLKQGMDNTENSKRYHPTSTPVIMGHIAVLGGWVRD
IVHGEPSGVVRAFDVRNGNVVWAWDVGQPENVTDPVKGRVYTLETPNVWTVPGFDKELNL
IYLPTGNGPPDYWGGDRNAAKEKYGSSVVAVDASTGETKWVFQTVHHDIWDYDLPSQPVL
FHMKNERGEEVPVLIQTTKTGQIYVLDRRTGKPVTRVEERPVAHDGAEGEHLSATQPFST
GMPQLGVEPLTEKSMWGVTPFDQLMCRIDFKESTYLGMYTPPSEKPYIEWPSLLGGMNWG
GITIDERTGTLFVNDMRMPLRMSLVRKEDMAKYKVSTDEVPGFMGTVRPQIAGPYGGVRI
DILQSALGVPCNTPPFGTMSAIDLNTRQLMWQVPMGSVEDTGPLGLKTHMHIPLGMPTLG
GPTSTASGLVFFAGTQDNYLRALDSATGKELWRARLPVGAVAAPLIYKSPKTGKEYVVIS
AGGASHSPDVGDDIIAFALEE