Protein Info for BWI76_RS15205 in Klebsiella michiganensis M5al
Annotation: succinate-semialdehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 77% identical to SAD_ECOLI: Succinate semialdehyde dehydrogenase [NAD(P)+] Sad (sad) from Escherichia coli (strain K12)
KEGG orthology group: K08324, aldehyde dehydrogenase family protein [EC: 1.2.1.-] (inferred from 88% identity to kpu:KP1_2675)MetaCyc: 77% identical to succinate semialdehyde dehydrogenase (NAD(P)+) Sad (Escherichia coli K-12 substr. MG1655)
Succinate-semialdehyde dehydrogenase. [EC: 1.2.1.24]; Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.24, 1.2.1.20]
Predicted SEED Role
"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)
MetaCyc Pathways
- superpathway of L-arginine and L-ornithine degradation (13/13 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (11/11 steps found)
- superpathway of 4-aminobutanoate degradation (3/3 steps found)
- L-lysine degradation X (5/6 steps found)
- 4-aminobutanoate degradation I (2/2 steps found)
- 4-aminobutanoate degradation III (2/2 steps found)
- GABA shunt I (3/4 steps found)
- L-lysine degradation I (5/7 steps found)
- GABA shunt II (2/4 steps found)
- 4-aminobutanoate degradation IV (1/3 steps found)
- N-methylpyrrolidone degradation (1/3 steps found)
- L-lysine degradation IV (2/5 steps found)
- L-lysine degradation III (2/6 steps found)
- superpathway of L-lysine degradation (12/43 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Arginine and proline metabolism
- Butanoate metabolism
- Geraniol degradation
- Glutamate metabolism
- Limonene and pinene degradation
- Lysine biosynthesis
- Lysine degradation
- Naphthalene and anthracene degradation
- Tryptophan metabolism
- Tyrosine metabolism
- Urea cycle and metabolism of amino groups
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.-, 1.2.1.16, 1.2.1.24
Use Curated BLAST to search for 1.2.1.- or 1.2.1.16 or 1.2.1.20 or 1.2.1.24
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285B464 at UniProt or InterPro
Protein Sequence (461 amino acids)
>BWI76_RS15205 succinate-semialdehyde dehydrogenase (Klebsiella michiganensis M5al) MNLSATHAVSVNPTTGETLSSLPWASEQQVDSAIALAEQGYRQWRKVSVAQRATTLRNVG AAMRARSEALAQMISLEMGKPIAQARGEVAKSANLCDWYAEHGPAMLNTEATLVEDNKAV IEYRPMGAILAIMPWNFPVWQVLRGAVPILLAGNSYLLKHAPNVLGSAAMIGEIFAAAGV PEGVFGWVNATNDGVSQMINDPRIAAVTVTGSVRAGKAIGAQAGAALKKCVLELGGSDPF IVLNDADLDEAVKAAVIGRYQNTGQVCAAAKRFIVEAGIAEAFTQKFVAAVAALKMGDPR DEQNYIGPMARFDLRDELHEQVRATLKEGATLLLGAEKIEGAGNYYAPTVLGNVTAEMTG FREELFGPVATITEARDADHALALANESEFGLSATVYTTSETQARRFADELECGGVFING YCASDARVAFGGVKKSGFGRELSHFGLHEFCNVQTVWRDRR