Protein Info for BWI76_RS15180 in Klebsiella michiganensis M5al
Annotation: altronate oxidoreductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 87% identical to UXAB_ECO24: Altronate oxidoreductase (uxaB) from Escherichia coli O139:H28 (strain E24377A / ETEC)
KEGG orthology group: None (inferred from 90% identity to eae:EAE_18645)MetaCyc: 87% identical to tagaturonate reductase (Escherichia coli K-12 substr. MG1655)
Tagaturonate reductase. [EC: 1.1.1.58]
Predicted SEED Role
"Altronate oxidoreductase (EC 1.1.1.58)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.58)
MetaCyc Pathways
- superpathway of hexuronide and hexuronate degradation (9/10 steps found)
- D-galacturonate degradation I (5/5 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.58
Use Curated BLAST to search for 1.1.1.58
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285B449 at UniProt or InterPro
Protein Sequence (483 amino acids)
>BWI76_RS15180 altronate oxidoreductase (Klebsiella michiganensis M5al) MKTLNRRDFPGAQYPERIIQFGEGNFLRAFIDWQIDLLNEHTDLNAGVVIVRPIESTFPP SLSVQDGLYTTIIRGLNEKGEAVSDARLIRSVNREISAYADYDELLRLAHNPDMRFVFSN TTEAGISYHAGDRFDDAPAVSYPAKLTRLLFERYSHFSGAADKGWVIVPCELIDYNGEAL RELVLRYAQEWALPEAFVTWLDEANAFCSTLVDRIVTGYPRDEAAQIEEQLGYKDAFLDT AEHFYLFVIQGPKSLAAELRLDKLPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAG LDTVGDAMNDAEICAFVEKAIYQEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIA LNGMTKYRTRILPQLLAGQKKAGKLPARLTFALAALIAFYRGERHGESYPVQDDSEWIES YQALWAQHRDRQISTRELVNAVLCVESHWEQDLTKVSGLAEQVAQDLDAILRDGMRAAVK PLC