Protein Info for BWI76_RS13725 in Klebsiella michiganensis M5al

Annotation: aromatic amino acid exporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 292 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 36 to 55 (20 residues), see Phobius details amino acids 64 to 86 (23 residues), see Phobius details amino acids 93 to 113 (21 residues), see Phobius details amino acids 120 to 137 (18 residues), see Phobius details amino acids 157 to 176 (20 residues), see Phobius details amino acids 185 to 203 (19 residues), see Phobius details amino acids 213 to 233 (21 residues), see Phobius details amino acids 244 to 264 (21 residues), see Phobius details amino acids 270 to 289 (20 residues), see Phobius details PF00892: EamA" amino acids 158 to 285 (128 residues), 33.8 bits, see alignment E=2e-12

Best Hits

Swiss-Prot: 77% identical to YDDG_ECOLI: Aromatic amino acid exporter YddG (yddG) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 90% identity to eae:EAE_19875)

MetaCyc: 77% identical to amino acid exporter YddG (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-265

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B3R0 at UniProt or InterPro

Protein Sequence (292 amino acids)

>BWI76_RS13725 aromatic amino acid exporter (Klebsiella michiganensis M5al)
MEKKRATLIGLAAIVLWSTMVGLIRGVSEGLGPVGGAAMLYSLSGMLLIFTVGFPQIRQI
PRPYLLAGSLLFVSYEICLALSVGLAGTRQQAIEVGMVNYLWPSLTILFAILFNGQKSSW
LVIPGLFLAIFGVTWVLGGEHGLNIDEIISNVVSSPLSYILAFIGAFIWAAYCTVTAKYA
KGKNGITLFVLLTALTLWLKFLFSEQPPMVFSWPVTIKLIALSVALGFGYAAWNVGILHG
NVSLLAAASYFTPVLSSALAAVLLSAALSWSFWQGAGMVCIGSLLCWQATRR