Protein Info for BWI76_RS13645 in Klebsiella michiganensis M5al

Annotation: N-hydroxyarylamine O-acetyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00797: Acetyltransf_2
  • amino acids 21 to 256 (236 residues), 276.4 bits, E=1.3e-86

Best Hits

Swiss-Prot: 72% identical to NHOA_ECOLI: Arylamine N-acetyltransferase (nhoA) from Escherichia coli (strain K12)

KEGG orthology group: K00675, N-hydroxyarylamine O-acetyltransferase [EC: 2.3.1.118] (inferred from 88% identity to kpe:KPK_2472)

MetaCyc: 72% identical to arylamine N-acetyltransferase (Escherichia coli K-12 substr. MG1655)
Arylamine N-acetyltransferase. [EC: 2.3.1.5]; N-hydroxyarylamine O-acetyltransferase. [EC: 2.3.1.5, 2.3.1.118]

Predicted SEED Role

"N-hydroxyarylamine O-acetyltransferase (EC 2.3.1.118)" (EC 2.3.1.118)

KEGG Metabolic Maps

• Caffeine metabolism
• Drug metabolism - other enzymes
• Trinitrotoluene degradation

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.118

Use Curated BLAST to search for 2.3.1.118 or 2.3.1.5

Sequence Analysis Tools

See A0A285B3P2 at UniProt or InterPro

Protein Sequence (281 amino acids)

>BWI76_RS13645 N-hydroxyarylamine O-acetyltransferase (Klebsiella michiganensis M5al)
MSPFLSAYFSRLGWVGTPDVSLNTLRELHIHHNGAIPFENLDVLLPREIHLDDRTLEDKL
IHGRRGGYCFEQNGLLERALREIGFNVRSLLGRVVLANPPHMPPRTHRLLLVEVEGERWI
ADVGFGGQTLTAPIKLLADIEQATLHGEYRLIYEGDEWALQFSHHGHWQSMYHFDLGRQY
AADYVMGNFWSAHWPQSHFRHHLLMCRHLPDGGKMTLTNFHFTHWDKNHVVEKLDLADVP
ALYEALKTRFGLGVDDAKYGFSEAELAAVMAAFDTHPEAGK