Protein Info for BWI76_RS12495 in Klebsiella michiganensis M5al

Annotation: 2-Cys peroxiredoxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08534: Redoxin
  • amino acids 20 to 163 (144 residues), 127.9 bits, E=2.9e-41
• PF00578: AhpC-TSA
  • amino acids 22 to 146 (125 residues), 57.7 bits, E=1.2e-19

Best Hits

Swiss-Prot: 83% identical to TPX_SHIFL: Thiol peroxidase (tpx) from Shigella flexneri

KEGG orthology group: K11065, thiol peroxidase, atypical 2-Cys peroxiredoxin [EC: 1.11.1.15] (inferred from 95% identity to kpu:KP1_2352)

MetaCyc: 83% identical to lipid hydroperoxide peroxidase (Escherichia coli K-12 substr. MG1655)
1.11.1.15-RXN [EC: 1.11.1.24]

Predicted SEED Role

"Thiol peroxidase, Tpx-type (EC 1.11.1.15)" in subsystem Thioredoxin-disulfide reductase (EC 1.11.1.15)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.24

Sequence Analysis Tools

See A0A285B2Y1 at UniProt or InterPro

Protein Sequence (169 amino acids)

>BWI76_RS12495 2-Cys peroxiredoxin (Klebsiella michiganensis M5al)
MSQTVHFQGNPVSVQGTIPQAGAKAQPFTLVAKDLSDVALSQFAGSRKVLNIFPSIDTGV
CAASVRKFNQLASELNNTVVLCISADLPFAQSRFCGAEGLNNVVTLSTLRGAQFLADYGV
AISAGPLAGLAARAVVVIDENDQVVYSQLVNEITEEPDYDAALAALKAQ