Protein Info for BWI76_RS09795 in Klebsiella michiganensis M5al

Annotation: lipid ABC transporter permease/ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 582 transmembrane" amino acids 21 to 44 (24 residues), see Phobius details amino acids 64 to 93 (30 residues), see Phobius details amino acids 142 to 162 (21 residues), see Phobius details amino acids 168 to 186 (19 residues), see Phobius details amino acids 246 to 270 (25 residues), see Phobius details amino acids 276 to 295 (20 residues), see Phobius details TIGR02203: lipid A export permease/ATP-binding protein MsbA" amino acids 12 to 581 (570 residues), 893.7 bits, see alignment E=2.5e-273 PF00664: ABC_membrane" amino acids 27 to 298 (272 residues), 207.4 bits, see alignment E=5.2e-65 PF00005: ABC_tran" amino acids 359 to 509 (151 residues), 121.2 bits, see alignment E=8.1e-39

Best Hits

Swiss-Prot: 93% identical to MSBA_SHIDS: Lipid A export ATP-binding/permease protein MsbA (msbA) from Shigella dysenteriae serotype 1 (strain Sd197)

KEGG orthology group: None (inferred from 96% identity to eae:EAE_15170)

MetaCyc: 93% identical to ATP-binding lipopolysaccharide transport protein (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-236 [EC: 7.5.2.6]; 7.5.2.6 [EC: 7.5.2.6]

Predicted SEED Role

"Lipid A export ATP-binding/permease protein MsbA" in subsystem ZZ gjo need homes

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B1M9 at UniProt or InterPro

Protein Sequence (582 amino acids)

>BWI76_RS09795 lipid ABC transporter permease/ATP-binding protein (Klebsiella michiganensis M5al)
MQNDKDLSTWQTFRRLWPIIAPFKPGLIVAAVALVLNAASDTFMLSLLKPLLDDGFGKTD
RSVLIWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFSHMMGMPVAFFDKQS
TGTLLSRITYDSEQVASSSSSALITVVREGASIIGLFVMMFYYSWQLSVILIVLAPIVSI
AIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLMFGGQAVETKRFDKVSNKMRLQ
GMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMETLTAGTITVVFSSMIALMRPLKS
LTNVNAQFQRGMAACQTLFAILDSEQEKDEGTRVIERAKGNLEFKNVTFRYPGREVAALR
NIDLNIPEGKTVALVGRSGSGKSTIASLITRFYDVDDGQILLDGHDLREYTLSSLRDQVA
LVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYAMDFINKMDNGLDTIIGENGVM
LSGGQRQRIAIARALLRNSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLS
TIEQADEIVVVEDGQIVERGSHTDLLEHKGVYAQLHKMQFGA