Protein Info for BWI76_RS09790 in Klebsiella michiganensis M5al

Annotation: ComEC family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 751 transmembrane" amino acids 7 to 29 (23 residues), see Phobius details amino acids 47 to 67 (21 residues), see Phobius details amino acids 180 to 201 (22 residues), see Phobius details amino acids 221 to 243 (23 residues), see Phobius details amino acids 255 to 274 (20 residues), see Phobius details amino acids 280 to 297 (18 residues), see Phobius details amino acids 304 to 321 (18 residues), see Phobius details amino acids 327 to 346 (20 residues), see Phobius details amino acids 359 to 383 (25 residues), see Phobius details amino acids 389 to 412 (24 residues), see Phobius details amino acids 421 to 439 (19 residues), see Phobius details amino acids 451 to 469 (19 residues), see Phobius details amino acids 474 to 491 (18 residues), see Phobius details TIGR00361: DNA internalization-related competence protein ComEC/Rec2" amino acids 66 to 718 (653 residues), 762.6 bits, see alignment E=3.1e-233 PF03772: Competence" amino acids 201 to 467 (267 residues), 164.2 bits, see alignment E=4e-52 TIGR00360: ComEC/Rec2-related protein" amino acids 221 to 404 (184 residues), 147.4 bits, see alignment E=5.1e-47 PF00753: Lactamase_B" amino acids 505 to 686 (182 residues), 74 bits, see alignment E=1.6e-24

Best Hits

Swiss-Prot: 61% identical to YCAI_ECOLI: Uncharacterized protein YcaI (ycaI) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 71% identity to eae:EAE_15165)

Predicted SEED Role

"DNA internalization-related competence protein ComEC/Rec2"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B1F9 at UniProt or InterPro

Protein Sequence (751 amino acids)

>BWI76_RS09790 ComEC family protein (Klebsiella michiganensis M5al)
MRLPQLAGCVIIGILPLLWLPVLPGRWVTWGLMVLALLIAQCRRRPAQYAALITLFFVWG
VLSARQTLWPTERLTDKNQRVEVELTATDGQTTHQGKIIRLDGRRLFPAPGISLYGNYLP
ETPCAGQVWAMTLRARPVHGQLNDGGFDSQRYALAQHRPLTGRFITAEIRERNCSLRARY
LASLNHTLAALPWQSVMLGLGMGERLAIPREIKSLMQETGISHLMAISGLHIALGASLGW
LLLRGAQFFLPCRWLGWRAPLLMGLASAIFYAGLTGMQPPALRTCVALAAGGALRLSGKR
WSPWQLWVCCIGAILFADPLAMLSESLWLSAFAVAALIFWYQLAPMPAGKKNWLLRQSLA
LCHLQIGLMFLLAPLQIALFHGISLTSVVANFIAVPLVTFVVVPLILAAMFLHLCAPSII
EMAVWQSADRILAILFWLLRQLPSGWLGLDARWLGISIVPWLALIVWRFHAWRTAPAFCL
TCLVLLSRPFWRSASVDEWRATMLDVGQGLAVVIERQGAAFLYDTGLAWPDGDSGQQIII
PWLRWHHLQLEGIVLSHEHLDHRGGLNSVLKAWPQTAVRSPLGWAGHLACRRGETWQWRG
LTFRALWPLPGATKAGNNRSCVVRIDDGQYSILLTGDIETPAELAMISHYWQHLASTLIQ
VPHHGSNTSSGIALLRSVGGKAALASASRYNAWRMPSAKVIQRYRNQRYQWFDTPHQGQI
TVVFSPDGWQIHGLRDQVLPRWYHQWFGGKA