Protein Info for BWI76_RS08730 in Klebsiella michiganensis M5al

Annotation: histidine utilization repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 241 TIGR02018: histidine utilization repressor" amino acids 12 to 240 (229 residues), 353 bits, see alignment E=3.1e-110 PF00392: GntR" amino acids 14 to 76 (63 residues), 82.3 bits, see alignment E=2.4e-27 PF07702: UTRA" amino acids 98 to 234 (137 residues), 123 bits, see alignment E=1.3e-39

Best Hits

Swiss-Prot: 93% identical to HUTC_KLEAE: Histidine utilization repressor (hutC) from Klebsiella aerogenes

KEGG orthology group: K05836, GntR family transcriptional regulator, histidine utilization repressor (inferred from 93% identity to kpn:KPN_00794)

Predicted SEED Role

"Histidine utilization repressor" in subsystem Histidine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B101 at UniProt or InterPro

Protein Sequence (241 amino acids)

>BWI76_RS08730 histidine utilization repressor (Klebsiella michiganensis M5al)
MFSSQPRSAPAPFYEKVKQAISEKIHSGVWRPHDRIPSEAELVAQFGFSRMTINRALREL
TDEGLLVRLQGVGTFVAEPKGQSALFEVRSIAEEIASRHHQHRCEVLLLEETQADLIQAA
ALNVAAGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYLRQDYTATTPHDYLSLIAPLT
EGEHIVEAVQATAEECALLHIHAHDPCLLIRRRTWSTTHIVSHARLLFPGSRYRLQGHFA
S