Protein Info for BWI76_RS06520 in Klebsiella michiganensis M5al

Annotation: trigger factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 PF05697: Trigger_N" amino acids 1 to 144 (144 residues), 151.4 bits, see alignment E=3.2e-48 TIGR00115: trigger factor" amino acids 13 to 412 (400 residues), 471.7 bits, see alignment E=9.6e-146 PF00254: FKBP_C" amino acids 158 to 237 (80 residues), 65 bits, see alignment E=9.6e-22 PF05698: Trigger_C" amino acids 262 to 412 (151 residues), 143.6 bits, see alignment E=9.1e-46

Best Hits

Swiss-Prot: 98% identical to TIG_KLEP3: Trigger factor (tig) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K03545, trigger factor (inferred from 98% identity to kpe:KPK_4284)

MetaCyc: 95% identical to trigger factor (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]

Predicted SEED Role

"Cell division trigger factor (EC 5.2.1.8)" in subsystem Bacterial Cell Division (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZQ0 at UniProt or InterPro

Protein Sequence (432 amino acids)

>BWI76_RS06520 trigger factor (Klebsiella michiganensis M5al)
MQVSVETTQGLGRRVTITIAADSIENAVKSELVNVAKKVRIDGFRKGKVPMNVVAQRYGA
SVRQDVLGDLMSRNFVDAIIKEKINPAGAPNYVPGEYKLGEDFTYAVEFEVYPEVELQGL
EAIEVEKPVVEVTDADVDTMLDTLRKQQANWKDKDGAVDAEDRVTVDFTGSVDGEEFEGG
KASDFVLAMGQGRMIPGFEDGIKGHKAGEEFTIDVTFPEEYHAENLKGKAAKFVINLKKV
EERELPELTEEFIKRFGVEDGSVAGLRAEVRKNMERELKGAVRNRVKSQAIEGLVKANDI
DVPAALIDSEIDVLRRQAAQRFGGNEQQALELPRELFEEQAKRRVVVGLLLGEVIRTNEL
KADEDRVKGLIEEMASAYEDPKEVVEFYSKNKELMDNMRNVALEEQAVEAVLAKAKVSEK
ATSFSELMNQQA