Protein Info for BWI76_RS06475 in Klebsiella michiganensis M5al

Annotation: protoheme IX farnesyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 295 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 37 to 59 (23 residues), see Phobius details amino acids 79 to 102 (24 residues), see Phobius details amino acids 107 to 126 (20 residues), see Phobius details amino acids 133 to 155 (23 residues), see Phobius details amino acids 161 to 182 (22 residues), see Phobius details amino acids 208 to 226 (19 residues), see Phobius details amino acids 232 to 251 (20 residues), see Phobius details amino acids 263 to 284 (22 residues), see Phobius details TIGR01473: protoheme IX farnesyltransferase" amino acids 3 to 281 (279 residues), 309.5 bits, see alignment E=1.4e-96 PF01040: UbiA" amino acids 18 to 267 (250 residues), 218.6 bits, see alignment E=4.4e-69

Best Hits

Swiss-Prot: 98% identical to CYOE_KLEP7: Protoheme IX farnesyltransferase (cyoE) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K02301, protoheme IX farnesyltransferase [EC: 2.5.1.-] (inferred from 98% identity to kpn:KPN_00390)

MetaCyc: 95% identical to heme O synthase (Escherichia coli K-12 substr. MG1655)
HEMEOSYN-RXN [EC: 2.5.1.141]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.-

Use Curated BLAST to search for 2.5.1.- or 2.5.1.141

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AZV3 at UniProt or InterPro

Protein Sequence (295 amino acids)

>BWI76_RS06475 protoheme IX farnesyltransferase (Klebsiella michiganensis M5al)
MFKQYLQVTKPGIIFGNLISVIGGFLLASKGHIDYPLFIWTLLGVSLVVASGCVFNNYID
RDIDRKMERTKNRVLVKGLISPEASLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYV
GVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSGAAILLAIFSLWQMPHSYAIA
IFRFKDYQAANIPVLPVVKGISVAKNHITVYIIAFTVATLMLSLGGYAGYKYLVVAAAVS
VWWLGMALRGYKVADDKVWARKLFVFSIVAITALSVMMSVDFMVPDSHNLLTMVR