Protein Info for BWI76_RS05175 in Klebsiella michiganensis M5al

Annotation: dGTPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 504 TIGR01353: putative dGTPase" amino acids 30 to 502 (473 residues), 468.3 bits, see alignment E=1.4e-144 PF01966: HD" amino acids 66 to 135 (70 residues), 31.7 bits, see alignment E=1.7e-11

Best Hits

Swiss-Prot: 89% identical to DGTP_KLEP7: Deoxyguanosinetriphosphate triphosphohydrolase (dgt) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: None (inferred from 91% identity to eae:EAE_11600)

MetaCyc: 86% identical to dGTP triphosphohydrolase (Escherichia coli K-12 substr. MG1655)
dGTPase. [EC: 3.1.5.1]

Predicted SEED Role

"Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1)" in subsystem Purine conversions (EC 3.1.5.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.5.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AYW3 at UniProt or InterPro

Protein Sequence (504 amino acids)

>BWI76_RS05175 dGTPase (Klebsiella michiganensis M5al)
MAKIDFRNKINWRRRYRSPQGVETEREILRIFESDRGRIINSPAIRRLQQKTQVFPLERN
AAVRTRLTHSLEVQQVGRYIAKEVLSRLKEQKLLESYGLDELTGPFESIVEMACLMHDIG
NPPFGHFGEAAINDWFSQRLFPGDAASQPLTDDRCVVAALRLQEGDSQLNELRRKVRQDL
CWFEGNAQGIRLVHTLMRMNLTWAQVGCILKYTRPAWWRGEPPASHNYLMKKPGYYLAEE
GYIARLRKELDLAPYNRFPLTWIMEAADDISYCVADLEDAVEKRIFSVEQLYQHLYEAWG
VHEKGSLFNQVVENAWEKSRANSLSRSTEDQFFMYLRVNTLNRLVPYAARRFIDNLPKIF
SGDFNHALLEDDSDCSQLLELYKNVAVKHVFSHPDVEQLELQGYRVISGLLDIYQPLLKL
SLDEFSLLVEKERVRSLPIASRLFQKLSTRHRLAYIEAVNKISRNNPEFPVLEYYYRCRL
IQDYISGMTDLYAWDEYRRLMAVE