Protein Info for BWI76_RS04585 in Klebsiella michiganensis M5al

Annotation: L-arabinose isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 PF02610: AraA_N" amino acids 7 to 173 (167 residues), 270.3 bits, see alignment E=8.8e-85 PF24856: AraA_central" amino acids 177 to 324 (148 residues), 243 bits, see alignment E=2.2e-76 PF11762: Arabinose_Iso_C" amino acids 328 to 472 (145 residues), 218 bits, see alignment E=6.2e-69

Best Hits

Swiss-Prot: 95% identical to ARAA_KLEP7: L-arabinose isomerase (araA) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K01804, L-arabinose isomerase [EC: 5.3.1.4] (inferred from 95% identity to kva:Kvar_4322)

MetaCyc: 90% identical to L-arabinose isomerase (Escherichia coli K-12 substr. MG1655)
L-arabinose isomerase. [EC: 5.3.1.4]

Predicted SEED Role

"L-arabinose isomerase (EC 5.3.1.4)" in subsystem L-Arabinose utilization (EC 5.3.1.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AYF0 at UniProt or InterPro

Protein Sequence (500 amino acids)

>BWI76_RS04585 L-arabinose isomerase (Klebsiella michiganensis M5al)
MTIFNNYEVWFVIGSQHLYGPEALRQVTKHAEHVVNSLNAEAKLPCKLVLKPLGTTPDEI
THICRDANYDDKCAGMVVWLHTFSPAKMWINGLTILNKPLMQFHTQFNAALPWDSIDMDF
MNLNQTAHGGREFGFIGARMRQQHSVVTGHWQDKEAHQRIGAWMRQAVSKQDTRHLKVCR
FGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNAVSDGEISALIDEYESSYRLT
PAVQIHGDKRQNLLDAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQG
YGFAGEGDWKTAALLRIMKVMATGLQGGTSFMEDYTYHFEKGNDLALGSHMLEVCPTIAT
AEKPILDVQPLGIGGKADPARIIFNTQTGPAIVASLIDLGDRYRLLVNTIETVKTPHELP
KLPVANALWKAHPDLRTASEAWIIAGGAHHTVFSHALTLDDMRQFAELQDIELTVIDNET
RLPSFKDALRWNEVYYGSKR