Protein Info for BWI76_RS04315 in Klebsiella michiganensis M5al

Annotation: Na+/H+ antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 391 transmembrane" amino acids 12 to 39 (28 residues), see Phobius details amino acids 59 to 78 (20 residues), see Phobius details amino acids 95 to 114 (20 residues), see Phobius details amino acids 126 to 145 (20 residues), see Phobius details amino acids 154 to 175 (22 residues), see Phobius details amino acids 181 to 200 (20 residues), see Phobius details amino acids 207 to 237 (31 residues), see Phobius details amino acids 257 to 276 (20 residues), see Phobius details amino acids 287 to 312 (26 residues), see Phobius details amino acids 328 to 351 (24 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 6 to 380 (375 residues), 500.6 bits, see alignment E=1.3e-154 TIGR00773: Na+/H+ antiporter NhaA" amino acids 7 to 380 (374 residues), 613.3 bits, see alignment E=7.9e-189

Best Hits

Swiss-Prot: 89% identical to NHAA1_KLEP7: Na(+)/H(+) antiporter NhaA 1 (nhaA1) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: None (inferred from 91% identity to eae:EAE_10825)

MetaCyc: 84% identical to Na+:H+ antiporter NhaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-129; TRANS-RXN-292

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AYG0 at UniProt or InterPro

Protein Sequence (391 amino acids)

>BWI76_RS04315 Na+/H+ antiporter NhaA (Klebsiella michiganensis M5al)
MKHLHRFFSSDASGGIILIIAAALAMLMANVGLTSGWYHAFLETPVQLKVGALEINKNML
LWINDALMAVFFLLIGLEVKREMNQGALASRRQAVFPVVAALGGMVVPALVYLAFNGQDP
IAREGWAIPAATDIAFALGVLALLGNRVPAALKIFLMALAIIDDLGAIIIIALFYTHDLS
VVSLVVAAGAIIVLAALNLCGVRRTGIYILVGAILWTAVLKSGVHATLAGVIVGFMIPLK
EQNGKSPAKQLEHVLHPWVAFLILPLFAFANAGVSLQGVTLEGLTSLLPLGIIAGLFIGK
PLGISVFCWLALKLKWASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPGLINW
AKLGILIGSILSAVTGYIILRKRVTDSGYAA