Protein Info for BWI76_RS04175 in Klebsiella michiganensis M5al

Annotation: energy-dependent translational throttle protein EttA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 555 TIGR03719: ATP-binding cassette protein, ChvD family" amino acids 2 to 553 (552 residues), 974.9 bits, see alignment E=1.2e-297 PF00005: ABC_tran" amino acids 22 to 191 (170 residues), 100.3 bits, see alignment E=3.6e-32 amino acids 340 to 473 (134 residues), 90.2 bits, see alignment E=4.9e-29 PF12848: ABC_tran_Xtn" amino acids 230 to 306 (77 residues), 45 bits, see alignment E=2.3e-15

Best Hits

Swiss-Prot: 96% identical to ETTA_ECO57: Energy-dependent translational throttle protein EttA (ettA) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 98% identity to kpe:KPK_4768)

Predicted SEED Role

"ABC transporter, ATP-binding protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AY92 at UniProt or InterPro

Protein Sequence (555 amino acids)

>BWI76_RS04175 energy-dependent translational throttle protein EttA (Klebsiella michiganensis M5al)
MAQFVYTMHRVGKVVPPKRHILKNISLSFFPGAKIGVLGLNGAGKSTLLRIMAGIDTDIE
GEARPQPGLKIGYLPQEPQLNPEQTVRESVEEAVAEVVNALKGLDEVYAKYAEPDADFDK
LAAQQGKFEEIIQAHDGHNLNVQLERAADALRLPDWDAKIANLSGGERRRVALCRLLLEK
PDMLLLDEPTNHLDAESVAWLERFLHDFEGTVVAITHDRYFLDNVAGWILELDRGEGIPW
EGNYSSWLEQKDQRLAQEASQEAARRKSIEKELEWVRQGAKGRQSKGKARLARFEELNNV
EYQKRNETNELFIPPGARLGDKVVEVSNLRKSYGDRLLIDDLSFSVPKGAIVGIIGPNGA
GKSTLFRMMSGQEQPDAGSITLGETVKLASVDQFRDAMDNSKTVWEEVSGGLDIMKIGNT
EMPSRAYVGRFNFKGVDQGKRVGELSGGERGRLHLAKLLQVGGNVLLLDEPTNDLDIETL
RALENALLEFPGCAMVISHDRWFLDRIATHILDYQDEGKVEFFEGNFTEYEEYKKRTLGA
DALEPKRIKYKRIAK