Protein Info for BWI76_RS03415 in Klebsiella michiganensis M5al

Annotation: LacI family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 342 PF00532: Peripla_BP_1" amino acids 69 to 258 (190 residues), 43.8 bits, see alignment E=3.6e-15 PF13407: Peripla_BP_4" amino acids 72 to 317 (246 residues), 60.7 bits, see alignment E=2.6e-20 PF13377: Peripla_BP_3" amino acids 189 to 332 (144 residues), 33.2 bits, see alignment E=8.7e-12

Best Hits

KEGG orthology group: K03435, LacI family transcriptional regulator, fructose operon transcriptional repressor (inferred from 64% identity to ddd:Dda3937_02532)

Predicted SEED Role

"transcriptional regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AXT5 at UniProt or InterPro

Protein Sequence (342 amino acids)

>BWI76_RS03415 LacI family transcriptional regulator (Klebsiella michiganensis M5al)
MENEFMAKTVEQVARALEISITTVRLVLGGKAEQYRISAKTQQRINDYIAENGLVVNHIA
RSLKLNKTETLGLVIPRLSNLFFSTLAEKLEACCRQAGYQLMIACTYSDSEHENSLVEGL
LARNVDGLFVVPSTRETQLHHQKVARKRPLVLLDRDFGESDVSLVVSDNYNGSKKLVQAM
TQAVDVSPIFFIAGDTQQPSIQRRLQGYLSELPTGKEWILSASHNRQEEGKQLMLDFLRQ
HREPPKAFIASSLPILEGTLSALRETYGFIPSDIPIGTFDEHQMLGFLPNAVWSMRQDED
AWAQHAFHLMQQKLQGENADVKITVPMTLIHRPLSVEKQRSQ