Protein Info for BWI76_RS01730 in Klebsiella michiganensis M5al

Annotation: PTS mannose/fructose/sorbose transporter subunit IIC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 265 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 33 to 61 (29 residues), see Phobius details amino acids 75 to 116 (42 residues), see Phobius details amino acids 141 to 166 (26 residues), see Phobius details amino acids 179 to 201 (23 residues), see Phobius details amino acids 209 to 239 (31 residues), see Phobius details TIGR00822: PTS system, mannose/fructose/sorbose family, IIC component" amino acids 1 to 265 (265 residues), 424.4 bits, see alignment E=8.1e-132 PF03609: EII-Sor" amino acids 6 to 237 (232 residues), 254.3 bits, see alignment E=5.2e-80

Best Hits

Swiss-Prot: 94% identical to PTRC_KLEPN: PTS system sorbose-specific EIIC component (sorA) from Klebsiella pneumoniae

KEGG orthology group: K02814, PTS system, sorbose-specific IIC component (inferred from 94% identity to kva:Kvar_4842)

MetaCyc: 63% identical to mannose-specific PTS enzyme IIC component (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-157 [EC: 2.7.1.199]; 2.7.1.199 [EC: 2.7.1.199]; TRANS-RXN-167 [EC: 2.7.1.199, 2.7.1.193]; TRANS-RXN-165 [EC: 2.7.1.199, 2.7.1.193, 2.7.1.191]; 2.7.1.191 [EC: 2.7.1.199, 2.7.1.193, 2.7.1.191]

Predicted SEED Role

"PTS system, sorbose-specific IIC component"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.191 or 2.7.1.193 or 2.7.1.199

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AW59 at UniProt or InterPro

Protein Sequence (265 amino acids)

>BWI76_RS01730 PTS mannose/fructose/sorbose transporter subunit IIC (Klebsiella michiganensis M5al)
MEISTLQIIAIFIFSCIAGMGSVLDEFQTHRPLIACTVIGLILGDLKTGIMLGGTLELIA
LGWMNVGAAQSPDSALASIISAILVIVGQQSIATGIAIALPVAAAGQVLTVFARTLTVVF
QHAADKAAEEARFGTIDLLHVSALGVQALRVAIPALIVSLFVSADMVSNMLNAIPEFVTR
GLQIAGGFIVVVGYAMVLRMMGVKYLMPFFFLGFLAGGYLDFSLLAFGGVGVIIALIYIQ
LNPQWRKSEPQAAATSSTALDQLDD