Protein Info for BWI76_RS01430 in Klebsiella michiganensis M5al

Annotation: type I pantothenate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 96% identical to COAA_KLEP3: Pantothenate kinase (coaA) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K00867, type I pantothenate kinase [EC: 2.7.1.33] (inferred from 96% identity to kpn:KPN_04352)

MetaCyc: 91% identical to pantothenate kinase (Escherichia coli K-12 substr. MG1655)
Pantetheine kinase. [EC: 2.7.1.34]; Pantothenate kinase. [EC: 2.7.1.34, 2.7.1.33]

Predicted SEED Role

"Pantothenate kinase (EC 2.7.1.33)" in subsystem Coenzyme A Biosynthesis (EC 2.7.1.33)

MetaCyc Pathways

superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
phosphopantothenate biosynthesis I (4/4 steps found)
phosphopantothenate biosynthesis II (1/3 steps found)
superpathway of coenzyme A biosynthesis II (plants) (5/10 steps found)

KEGG Metabolic Maps

Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.33 or 2.7.1.34

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AW60 at UniProt or InterPro

Protein Sequence (316 amino acids)

>BWI76_RS01430 type I pantothenate kinase (Klebsiella michiganensis M5al)
MSLKEQTLMTPYLQFNRDQWAALRDSVPMTLTEEEITRLKGINEDLSLEEVAEIYLPLSR
LLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRH
VELITTDGFLHPNAVLKERGLMKKKGFPQSYDMHRLVKFVSDLKSGVPDATAPVYSHLIY
DVIPDGDKTVTQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEELLKTWY
INRFLKFREGAFTDPDSYFHNYAQLSKDEAINIATSLWNEINLLNLKENILPTRERASLI
MTKSANHSVNQVRLRK