Protein Info for BWI76_RS00850 in Klebsiella michiganensis M5al
Annotation: acetylglutamate kinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 96% identical to ARGB_KLEP3: Acetylglutamate kinase (argB) from Klebsiella pneumoniae (strain 342)
KEGG orthology group: K00930, acetylglutamate/acetylaminoadipate kinase [EC: 2.7.2.- 2.7.2.8] (inferred from 95% identity to kpn:KPN_04248)MetaCyc: 94% identical to acetylglutamate kinase (Escherichia coli K-12 substr. MG1655)
Acetylglutamate kinase. [EC: 2.7.2.8]
Predicted SEED Role
"Acetylglutamate kinase (EC 2.7.2.8)" in subsystem Arginine Biosynthesis extended (EC 2.7.2.8)
MetaCyc Pathways
- superpathway of arginine and polyamine biosynthesis (16/17 steps found)
- L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
- L-arginine biosynthesis II (acetyl cycle) (9/10 steps found)
- L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
- L-ornithine biosynthesis I (5/5 steps found)
KEGG Metabolic Maps
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Lysine biosynthesis
- Urea cycle and metabolism of amino groups
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.2.- or 2.7.2.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A285AVQ8 at UniProt or InterPro
Protein Sequence (257 amino acids)
>BWI76_RS00850 acetylglutamate kinase (Klebsiella michiganensis M5al) MNPLIIKLGGVLLDSEEALERLFTALVNYRESHQRPLIIVHGGGCVVDELMKQLNLPVNK KNGLRVTPADQIDIITGALAGTANKTLLAWAKKHGLAAVGLFLGDGDSVKVTQLDEELGH VGFAQPGSPALINTLLAGGYMPVVSSIGVTDEGELMNVNADQAATALAATLGADLILLSD VSGILDGKGQRIAEMTAEKAEQLIEQGIITDGMIVKVNAALDAARTLGRPVDIASWRHAE QLPALFNGTPIGTRILA