Protein Info for BWI76_RS00725 in Klebsiella michiganensis M5al

Annotation: periplasmic repressor CpxP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 167 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF07813: LTXXQ" amino acids 41 to 135 (95 residues), 77.4 bits, see alignment E=1.2e-25

Best Hits

Swiss-Prot: 77% identical to CPXP_ECOLI: Periplasmic protein CpxP (cpxP) from Escherichia coli (strain K12)

KEGG orthology group: K06006, periplasmic protein CpxP (inferred from 96% identity to kpu:KP1_0080)

Predicted SEED Role

"P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285AVP9 at UniProt or InterPro

Protein Sequence (167 amino acids)

>BWI76_RS00725 periplasmic repressor CpxP (Klebsiella michiganensis M5al)
MRNVIAAVMASTLALSAYSQAAEVVTSVNWLPGDESVQRSSQSHMFDGISLTEQQRQQLR
DLMQRARHDRPPVNVSEMETMHRLVTAENFDENAVRAQADKMAQEQVARQVEMAKVRNQM
YHLLTPEQQAVLNAKHQQRMDQLREVARMQKGSAMMLSSSSNTLQPQ