Protein Info for BPHYT_RS23930 in Burkholderia phytofirmans PsJN

Annotation: triphosphoribosyl-dephospho-CoA synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 307 transmembrane" amino acids 120 to 139 (20 residues), see Phobius details TIGR03132: triphosphoribosyl-dephospho-CoA synthase MdcB" amino acids 26 to 293 (268 residues), 313.8 bits, see alignment E=5.2e-98 PF01874: CitG" amino acids 29 to 291 (263 residues), 241.5 bits, see alignment E=7e-76

Best Hits

Swiss-Prot: 60% identical to MDCB_AZOVD: Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (mdcB) from Azotobacter vinelandii (strain DJ / ATCC BAA-1303)

KEGG orthology group: K13930, triphosphoribosyl-dephospho-CoA synthase [EC: 2.7.8.25] (inferred from 100% identity to bpy:Bphyt_4820)

Predicted SEED Role

"Triphosphoribosyl-dephospho-CoA synthetase (EC 2.7.8.25)" in subsystem Malonate decarboxylase (EC 2.7.8.25)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2TBI2 at UniProt or InterPro

Protein Sequence (307 amino acids)

>BPHYT_RS23930 triphosphoribosyl-dephospho-CoA synthase (Burkholderia phytofirmans PsJN)
MASPALLAREEAQARCANAVRTLSDAQLARYAITALIDEAQLTPKPALVDRRGSGAHRDL
DLDTMLRSAQALEPTFAALARAARRRGEPSALLRTELAQIGRAGELDMLNATGGSNAHRG
AIWIVGLLVAGAALPAGAMRPNAARISTRAAQIACFPDRFAAPSDSHGERARQRYQVGGA
RREAQDGFPHVIDVGLPALLAARQRGIDENAARVDALLSIMATLDDTCLLHRAGLPGLHA
GQHGAQRVLDAGGSSTAAGRAALAALEHDLLTLNASPGGAADLLAATLFLDMLAHHDADR
SLDSWNI