Protein Info for BPHYT_RS19585 in Burkholderia phytofirmans PsJN

Annotation: cobalamin biosynthesis protein CobW

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 438 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF02492: cobW" amino acids 7 to 208 (202 residues), 193.6 bits, see alignment E=2.4e-61 PF07683: CobW_C" amino acids 266 to 386 (121 residues), 81.2 bits, see alignment E=4.1e-27

Best Hits

KEGG orthology group: None (inferred from 100% identity to bpy:Bphyt_3934)

Predicted SEED Role

"Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B2T7P0 at UniProt or InterPro

Protein Sequence (438 amino acids)

>BPHYT_RS19585 cobalamin biosynthesis protein CobW (Burkholderia phytofirmans PsJN)
MNQPLLPVTVLSGFLGAGKTTLLNHILANRAGLRVAVIVNDLAAVNIDATLVRDAAALSH
VEEQLVELSNGCICCTLRDDLRVEIKRLADEQRFDAILIESTGVAEPMPIAETFTFVDDE
GASLSDVARLDTMVTVVDAFNFLRDYGSADALAERGIAATEEDDRTLVELLIEQIEFCDV
LVVNKADLVSADELTRLQRILGRINPRAVQVVARFGEVPLAQVLNTGRFDFDEAESAPGW
LASLNHEHDHEHGHAHHGEADEFGIGNFIYRARRPFHPERLWALLHQEWKGVLRSKGFFW
LATRNDIAGSLSQAGGACRHGPAGMWWAAQDRSEWPDGDDELAAEIAADWYGDPDDLSIG
DRRQELVMIGVGIDAAVWKAKFDACLLTDEEYAQGPQAWAQFADPFPAWDFDEDDHDHHD
HNHDHDGHGHGEIVHRHD