Protein Info for BBR_RS19145 in Bifidobacterium breve UCC2003

Annotation: NCS2 family permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 464 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 45 to 68 (24 residues), see Phobius details amino acids 79 to 96 (18 residues), see Phobius details amino acids 100 to 118 (19 residues), see Phobius details amino acids 132 to 153 (22 residues), see Phobius details amino acids 182 to 199 (18 residues), see Phobius details amino acids 206 to 224 (19 residues), see Phobius details amino acids 260 to 283 (24 residues), see Phobius details amino acids 349 to 369 (21 residues), see Phobius details amino acids 375 to 392 (18 residues), see Phobius details amino acids 404 to 430 (27 residues), see Phobius details amino acids 445 to 463 (19 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 17 to 423 (407 residues), 145.2 bits, see alignment E=1.2e-46

Best Hits

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 97% identity to blb:BBMN68_1577)

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (464 amino acids)

>BBR_RS19145 NCS2 family permease (Bifidobacterium breve UCC2003)
MEKFFHLKENGTTVSTEILAGLTTFFAMAYIIVVNPQILSQTGMPWGGVFLATIIAAIIG
TLVMGLFANVPYAQAAGMGLNAFFTYTVCFGLGFSWQQTMCMVFLCGLINIIITVTKIRK
MIIMAIPESLQHAIGGGIGLFVAYVGMLNVGLIKFTPGDPKAAAKGGAVAATPGLANFND
KVLWVFLIGLVLAIVFTVMKVKGGMLLAIAVTTVIGIPFGVTTWSDSQSLGQTFSELPQT
FGAIFSAEGFPALFSDPAKLPLVIVTIFAFSMSDTFDTLGTFIGTGRRTGIFSAEDEKAL
ENGHGFSSKMDKALFADSIATSIGAICGTSNTTTYVESSAGIAAGGRTGLTSVVVAICFA
LSVFFAPVISAVPSAATAGVLVIVGCMMAASLKEVKWDDIAEAIPAFFAAVFMAFSYSIS
YGIAGGFIMYCIVKTCKGKAKEVHPIIWIVSALFILDFVCMAIL