Protein Info for BBR_RS15705 in Bifidobacterium breve UCC2003

Annotation: ribosome biogenesis GTPase Der

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 708 TIGR00017: cytidylate kinase" amino acids 3 to 224 (222 residues), 139.4 bits, see alignment E=2.8e-44 PF02224: Cytidylate_kin" amino acids 4 to 227 (224 residues), 149.9 bits, see alignment E=6.7e-47 TIGR03594: ribosome-associated GTPase EngA" amino acids 274 to 700 (427 residues), 515.1 bits, see alignment E=3.4e-158 PF01926: MMR_HSR1" amino acids 275 to 389 (115 residues), 91.6 bits, see alignment E=3e-29 amino acids 449 to 567 (119 residues), 84.2 bits, see alignment E=5.9e-27 TIGR00231: small GTP-binding protein domain" amino acids 275 to 424 (150 residues), 85.5 bits, see alignment E=6.8e-28 amino acids 448 to 586 (139 residues), 67.7 bits, see alignment E=2.1e-22 PF02421: FeoB_N" amino acids 275 to 400 (126 residues), 41.8 bits, see alignment E=6.5e-14 amino acids 449 to 574 (126 residues), 37.5 bits, see alignment E=1.4e-12 PF04548: AIG1" amino acids 276 to 378 (103 residues), 30.5 bits, see alignment E=1.8e-10 PF00009: GTP_EFTU" amino acids 277 to 397 (121 residues), 29.9 bits, see alignment E=3.3e-10 PF14714: KH_dom-like" amino acids 623 to 699 (77 residues), 88.2 bits, see alignment E=2.8e-28

Best Hits

KEGG orthology group: K03977, GTP-binding protein (inferred from 94% identity to blj:BLD_0463)

Predicted SEED Role

"GTP-binding protein EngA" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (708 amino acids)

>BBR_RS15705 ribosome biogenesis GTPase Der (Bifidobacterium breve UCC2003)
MIRVAIDGPAGVGKSSTSKALAKYFNYAYLDTGAMYRACAWWCLKSGIDLDAETVDERVI
TETVGEFFTGDHFDISVDPDDPRVYADGEDISEAIRSTEVSTHVSKVSNVIPVRNVLIAA
QRAYIAREASLDSFSGGLGVVAEGRDITTVVAPDAEVRILLTAREEVRQARRTGQAVKGV
GAEDVAARDKADSKVTSFLSAADGVTTIDNSDMDFEHTLDVMIKLIEDAIENQEYERYAA
NLEGYDLDEGDEDLISGRGFEDGARKSGPKPVGVLAIVGRPNVGKSSLVNRILGRRAAVV
EDTPGVTRDRVSYDAEWAGTDFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVD
GQVGMTTTDERIVKMLRASGKPVVLAVNKIDDNASEYLAAEFWKLGLGEPYSISAMHGRG
VGDLLDVALGKLKEAEKASGYLTPSGLRRVALVGRPNVGKSSLLNQLAHSERAVVNDLAG
TTRDPVDEIVDIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERSELALILFDAS
QPISDQDLKVMSTAVDAGRAIVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSA
KTGWHTNRLARAMNTALESWDQRIPTGKLNAFLGRIQAAHPHPLRGGKQPRILFATQAST
RPPRFVIFATGFLEHGYRRYIERQLREEFGFEGTPIQISVNIREKKRK