Protein Info for BBR_RS14235 in Bifidobacterium breve UCC2003

Annotation: DNA-binding response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 240 PF00072: Response_reg" amino acids 15 to 122 (108 residues), 96.9 bits, see alignment E=8.6e-32 PF00486: Trans_reg_C" amino acids 164 to 235 (72 residues), 86.7 bits, see alignment E=9.2e-29

Best Hits

Swiss-Prot: 42% identical to MTRA_MYCS2: DNA-binding response regulator MtrA (mtrA) from Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

KEGG orthology group: None (inferred from 97% identity to bln:Blon_1762)

Predicted SEED Role

"Response regulator receiver:Transcriptional regulatory protein, C-terminal"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (240 amino acids)

>BBR_RS14235 DNA-binding response regulator (Bifidobacterium breve UCC2003)
MLNTTARQNTAPRTVLVVEDEPTLATAIAQRITAEGWTARVAGDGASAVQAALQLKPDLV
IMDIMLPVMDGLEATKRIVAERPVPVLILTARDDETDKVIGLGAGADDYMTKPFSMRELI
ARCKALLRRVERAKVIAKNSENEKILDFGSMVIDPAQRIVTVNGEQVHLTPTEFDLLATL
ARRPKSVLTREKLLEEVWDWVDASGTRTVDSHVKALRHKLGADMIRTVHGVGYAFEPPTE