Protein Info for BBR_RS13775 in Bifidobacterium breve UCC2003

Annotation: isoprenyl transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 262 TIGR00055: di-trans,poly-cis-decaprenylcistransferase" amino acids 32 to 259 (228 residues), 229.8 bits, see alignment E=1.4e-72 PF01255: Prenyltransf" amino acids 39 to 259 (221 residues), 247.5 bits, see alignment E=5.8e-78

Best Hits

Swiss-Prot: 95% identical to ISPT_BIFLO: Isoprenyl transferase (uppS) from Bifidobacterium longum (strain NCC 2705)

KEGG orthology group: K00806, undecaprenyl diphosphate synthase [EC: 2.5.1.31] (inferred from 95% identity to bln:Blon_0783)

MetaCyc: 59% identical to (2Z,6E)-farnesyl diphosphate mono-trans,poly-cis-dodecaprenyl diphosphate synthase (Thermobifida fusca)
RXN-11487 [EC: 2.5.1.88]

Predicted SEED Role

"Undecaprenyl diphosphate synthase (EC 2.5.1.31)" (EC 2.5.1.31)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.31 or 2.5.1.88

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (262 amino acids)

>BBR_RS13775 isoprenyl transferase (Bifidobacterium breve UCC2003)
MAFENVDYTSLDIPAAPFSDPSRIPDFPKNKVPRHVGVIMDGNGRWAKQRGMIRTNGHQA
AEPVVFDTIAGAIEAGVRYLSLYTFSTENWKRSPQEVRFLMGFSREIIHRRVAQMDEWGV
RVRWSGRRPKLWKSVIDELEVAMERTKNNKVIDVVFCINYGGRAEIADACAAIAREVRDG
RISGDRVTEKMVADHLYNPDIPDCDLVIRTSGEQRTSNFLPWQAAYAELDFVPELFPDCG
REVLWRAIDNYIHRDRRFGGVK