Protein Info for Ac3H11_482 in Acidovorax sp. GW101-3H11

Annotation: RND multidrug efflux transporter; Acriflavin resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1053 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details amino acids 29 to 29 (1 residues), see Phobius details transmembrane" amino acids 28 to 28 (1 residues), see Phobius details amino acids 30 to 30 (1 residues), see Phobius details amino acids 333 to 352 (20 residues), see Phobius details amino acids 359 to 381 (23 residues), see Phobius details amino acids 387 to 409 (23 residues), see Phobius details amino acids 430 to 450 (21 residues), see Phobius details amino acids 462 to 485 (24 residues), see Phobius details amino acids 545 to 566 (22 residues), see Phobius details amino acids 867 to 888 (22 residues), see Phobius details amino acids 894 to 915 (22 residues), see Phobius details amino acids 921 to 945 (25 residues), see Phobius details amino acids 967 to 987 (21 residues), see Phobius details amino acids 998 to 1021 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 525 (522 residues), 583.7 bits, see alignment E=6.6e-179 amino acids 540 to 1024 (485 residues), 400.5 bits, see alignment E=1.5e-123 PF03176: MMPL" amino acids 331 to 494 (164 residues), 47.1 bits, see alignment E=1.6e-16

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 85% identity to vei:Veis_0778)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LI32 at UniProt or InterPro

Protein Sequence (1053 amino acids)

>Ac3H11_482 RND multidrug efflux transporter; Acriflavin resistance protein (Acidovorax sp. GW101-3H11)
MQLAEISIRRPVFATVLSLLVLLIGAVSFTRLSVREYPKIDEPVVTVSVRYAGASAEVIE
SQVTKPLEDSIAGIDAVDVITSISRAEQSQISVRFRLEKDADNAAAEVRDRTARVRNRLP
TAVDEPVIAKVEADASPVMWLAFSSDTRSPLEINDLINRIVKPRLQTVTGVADVPIYGER
KYAMRVWLDPERMAGYRLTTQDVEDAIRRNNLELPAGRIESQQREFSVTSQTDLKTPAQF
SNIVIRTVNGFPVRIQDVARVEEGAASDRSRVRLNGRDAISVGVIRQATANPLELSQGVR
AMLPLLKADLPPDIGIDVANDNSLFIDRSIKSVYTTIAEAVVLVALVIFVFLRTFRASII
PIVTIPVSLVGSFALMSLAGFSINTLTLLALVLAIGLVVDDAIVMLENIYRHIEEGLDPF
SAAIKGAREIGFAIVAMTLTLVAVYAPLAFTPGRTGRLFVEFALALAGAVVVSGFVALTL
SPMMCSLLLKHNPKPNWFDRSMERWLTALSDVYGRLLRWIVTARWGGGKGSAAGGGVRGA
IFQARWIVVGVMALSGLALALVFPTMRQELSPLEDRGTILASVTAPDGATLDYTNRYALE
LEKIGTTYPEFDRVFANIGNPTVAQGSVIYRTVDWESRNRTTLDLAKELQPKVAGLPGVN
AFLITPPSLGQGFRSRPLTYVIQTSDSYENLSKVVAAFMAEIAQNPGIVGPDVDLRLNKP
ELRIEVNRERAADLGVSVEVVAKAIETMLGGRTVTRYKRDAEQYDVIVQTEARGRTTPEN
IDTIYVRGRNEAMIPLSSLVNVRESVSPRELNHFGQRRSATITANLSSDYSLGQALTFMN
ETAAKVLKPGYTTDLNDTSREFKNSQGALGVVFVLALVFIFLVLAAQFESFIDPLVIMVS
VPLSMIGALLALKWSGGSLNVYSQIGLITLVGLITKHGILIVEFTNQLREEGMEMVDALV
KASAQRLRPILMTTGAMVLGAIPLALAKGAGAETRMQIGWVIVGGMSLGTLLTIFVVPTM
YTLFARKAVPGANTAVAAEEPEHPLHPHDYVAK