Protein Info for Ac3H11_4550 in Acidovorax sp. GW101-3H11

Annotation: Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details TIGR03431: phosphonate ABC transporter, periplasmic phosphonate binding protein" amino acids 1 to 283 (283 residues), 341 bits, see alignment E=6e-106 TIGR01098: phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein" amino acids 21 to 246 (226 residues), 272 bits, see alignment E=4.9e-85 PF12974: Phosphonate-bd" amino acids 26 to 273 (248 residues), 248.5 bits, see alignment E=3.3e-78

Best Hits

Swiss-Prot: 59% identical to PHND_ECOLI: Phosphonates-binding periplasmic protein (phnD) from Escherichia coli (strain K12)

KEGG orthology group: K02044, phosphonate transport system substrate-binding protein (inferred from 83% identity to vei:Veis_2965)

Predicted SEED Role

"Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1)" in subsystem ABC transporter alkylphosphonate (TC 3.A.1.9.1) (TC 3.A.1.9.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LP36 at UniProt or InterPro

Protein Sequence (315 amino acids)

>Ac3H11_4550 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) (Acidovorax sp. GW101-3H11)
MFKKLCAALTLGLGLTTGALAQDINFGMISTEASQNLKADWQPLLDDMAKQTGLKINAFF
ASDYAGLIEAMRFNKMQVAWLGNKSAMEAVDRANGEVFAQMVNADGTQGYYSHLIVHKDS
PLNTLDDVLKNGKSLNFGNGDPNSTSGFLVPGYYAFAQNKIDAKTHFKVVRSANHETNAL
AVANKQVDVATNNSENLEKFKERQPEKFKDIKIVWTSPLIALDPLVMRKDLPEPLKAKIK
DFFYNYAKTDAREKEIVMKISKLSGFKPSTNAQLTPIRQLDLFGKRNKIEADATLADSDK
KTRLAEIDQQLASLK