Protein Info for Ac3H11_4548 in Acidovorax sp. GW101-3H11

Annotation: Metal-dependent hydrolase involved in phosphonate metabolism

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 384 TIGR02318: phosphonate metabolism protein PhnM" amino acids 6 to 383 (378 residues), 467.6 bits, see alignment E=1.4e-144 PF07969: Amidohydro_3" amino acids 235 to 383 (149 residues), 31.5 bits, see alignment E=1.4e-11 PF01979: Amidohydro_1" amino acids 282 to 382 (101 residues), 26.9 bits, see alignment E=2.9e-10

Best Hits

KEGG orthology group: K06162, PhnM protein (inferred from 85% identity to vei:Veis_2963)

Predicted SEED Role

"Metal-dependent hydrolase involved in phosphonate metabolism" in subsystem Alkylphosphonate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LP10 at UniProt or InterPro

Protein Sequence (384 amino acids)

>Ac3H11_4548 Metal-dependent hydrolase involved in phosphonate metabolism (Acidovorax sp. GW101-3H11)
MTATVFKNARMVLPGEVVQGSLQVEGGRIASLDSGATSALQGIDLRGDYLLPGLVEIHTD
NFERHLMPRPKVQWAEMPALLAHDAEIAAAGITTVLDALGVGEADVDSLRGSAWNRVLDT
IDTCTERNLLRADHHLHVRCELPAPNTIDLFEPFHGHQRLSLISLMDHTPGQRQWENIEQ
ARTYYTGKKGWSAEKFERQVAHAATLQAQYAEPHRAYFVDYCRTHGISLASHDDTTVAHV
EQAHAEGAAMSEFPTTLAAAQAAHERGLLTVMGGPNVVRGGSHSGNVAAADLARRGLLDI
LSSDYVPGSLLSAVMRLVQDDILPLPQAVATVTRNPAKAAGMVDRGALAPGLRADLVQVH
MAELPDGGRQAVVRGVWREGQRVL