Protein Info for Ac3H11_4484 in Acidovorax sp. GW101-3H11

Annotation: Glycine cleavage system transcriptional activator GcvA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 301 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details PF00126: HTH_1" amino acids 23 to 76 (54 residues), 61 bits, see alignment E=8.8e-21 PF03466: LysR_substrate" amino acids 101 to 300 (200 residues), 114.2 bits, see alignment E=5.8e-37

Best Hits

KEGG orthology group: None (inferred from 89% identity to aav:Aave_0647)

Predicted SEED Role

"Glycine cleavage system transcriptional activator GcvA" in subsystem Glycine cleavage system or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LMI5 at UniProt or InterPro

Protein Sequence (301 amino acids)

>Ac3H11_4484 Glycine cleavage system transcriptional activator GcvA (Acidovorax sp. GW101-3H11)
MATALPSSFLSSAARRIPPIQCLLTFEALARLRSVTQTADELCVTPSAVSHRVKQLEQIL
GVQLFGRADFSLTTEGSAYLAHVREGLTALQRFPGQAAAPGRRRLKLAVTPTFARTILIP
RLRQFTEAYPEIDLALQVSIPLLDVVAEDADLMVRFGPGHYADVEHVELARDVVTPLASP
AFVREHGPFDRPEDLEGVPLLRSPLEPWRTWFAATGLDWAEPNEGSQFNDIGLMCDAAAA
GMGVALVRLKLGAPWLENGTLVRLFAHDAPSPHAHYLCWRTGTMDRWECAAFAEWLRKTM
A