Protein Info for Ac3H11_4390 in Acidovorax sp. GW101-3H11

Annotation: integral membrane sensor signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 transmembrane" amino acids 21 to 40 (20 residues), see Phobius details amino acids 169 to 190 (22 residues), see Phobius details PF00672: HAMP" amino acids 189 to 240 (52 residues), 40.5 bits, see alignment 4.2e-14 PF00512: HisKA" amino acids 246 to 304 (59 residues), 39.1 bits, see alignment E=9.8e-14 PF02518: HATPase_c" amino acids 346 to 453 (108 residues), 77 bits, see alignment E=2.3e-25

Best Hits

Predicted SEED Role

"integral membrane sensor signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165K516 at UniProt or InterPro

Protein Sequence (460 amino acids)

>Ac3H11_4390 integral membrane sensor signal transduction histidine kinase (Acidovorax sp. GW101-3H11)
MTAPIATARRGLWPRSLLGRNLLLMAALIVLGQLLAAVLVRQMIFQPRVAVVADGVARNV
AALRAGLQALPPAQRAAFVDAFNQQAVAATPPVAPQSAARRALLSPMERQFVLAVARRLG
VDDAATSPQPLWRRDSTGMLALRVDHPGADGPESYWLHLPSVFPTRTFTGAWLAATLASM
LLALLGAWWLQRHIHRPLAQVVGAARQLAQGQAPAVLPEAGPEEIATVARSFNHMAQSLA
AADHERALMLAGVSHDLRTPLTKLRLGVEIAGAQVDAPLAASMARSIDEMDGIVGQFLQF
ARSGEAEAPTPASLNDLAQAVAEAQADHGRTVRLELGALPEVPVRPQALRRALDNLVENA
WRHGQPPVVLRTGADANSVWLEVQDQGPGIRADDMDRMRQPFARGGGTARTGPPGAGLGL
AIVERVARSHGGRLELHSAPGAGLRARLVLPFQAKMAATA