Protein Info for Ac3H11_4269 in Acidovorax sp. GW101-3H11

Annotation: Glutathione-regulated potassium-efflux system protein KefB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 687 transmembrane" amino acids 28 to 47 (20 residues), see Phobius details amino acids 55 to 73 (19 residues), see Phobius details amino acids 81 to 100 (20 residues), see Phobius details amino acids 110 to 133 (24 residues), see Phobius details amino acids 144 to 167 (24 residues), see Phobius details amino acids 180 to 202 (23 residues), see Phobius details amino acids 208 to 228 (21 residues), see Phobius details amino acids 249 to 283 (35 residues), see Phobius details amino acids 299 to 320 (22 residues), see Phobius details amino acids 325 to 348 (24 residues), see Phobius details amino acids 358 to 376 (19 residues), see Phobius details amino acids 387 to 408 (22 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 33 to 405 (373 residues), 218.6 bits, see alignment E=1.9e-68 TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 37 to 316 (280 residues), 243.5 bits, see alignment E=1.5e-76 PF02254: TrkA_N" amino acids 442 to 555 (114 residues), 90.9 bits, see alignment E=1.1e-29 PF02080: TrkA_C" amino acids 618 to 683 (66 residues), 36 bits, see alignment E=8e-13

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 89% identity to vei:Veis_0155)

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefB" in subsystem Glutathione-regulated potassium-efflux system and associated functions

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165K5R8 at UniProt or InterPro

Protein Sequence (687 amino acids)

>Ac3H11_4269 Glutathione-regulated potassium-efflux system protein KefB (Acidovorax sp. GW101-3H11)
MPSGTDRASPAENILAGAQASDSIEPMSSLALTLLYLLAAVLGVVTCRSLKLPPMLGYLA
AGVLIGPHALALAQNSEGVRHLGEFGVVFLMFAIGLEFSLPKLRAMRKQVFGLGLMQVVL
TMVVLTVLALVLSRWAGGVWDMGWQTALALSGVMAMSSTAIVVKLMAERAELESEHGRRV
MGILLFQDLAVVPLLVLIPALGSSPDQLLTSLGWALIKATVLVGLLLTGGQRLMRWWLTL
VARRKSDELFMLNLLLITLGLAWLTEVAGLSLALGAFIAGVLVSETEYKHQVGTDIRPFH
DVLLGLFFITIGMMLDWHILVDRWALVLALLVVPLLLKLVIILVLARGMGATTGVALRTG
LYLAQAGEFGFVLLSLTQGNGLVQPALMNPILAAMVLSMLATPFLIMYSNRIVMKLVASD
WLQQSLQMTSIARKSINTSKHVIICGYGRCGQNLARMLEHEGIPYMALDLDPDRVRQAAA
AGDSVVYGDATRLQALMAAGLVRASAVAVTYIDVPAALKVLANARSHAPQVPVVVRTQDD
AHLDKLQEAGATEVVPEAIEGSLMLASHALALVGVPMRRVLRLVQDQRDARYNLLRGYFH
GADDDTVNERDQERLSTLNLPPGATALGHSLGQLALPAMGVRVVNLRRGNGHLSAAVDEA
LLAEGDTLVLSGHPAALALAEDKLLRG