Protein Info for Ac3H11_4154 in Acidovorax sp. GW101-3H11

Annotation: diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 804 signal peptide" amino acids 13 to 13 (1 residues), see Phobius details transmembrane" amino acids 14 to 34 (21 residues), see Phobius details amino acids 152 to 175 (24 residues), see Phobius details PF00989: PAS" amino acids 247 to 359 (113 residues), 35.7 bits, see alignment E=1.9e-12 PF08448: PAS_4" amino acids 253 to 362 (110 residues), 27.1 bits, see alignment E=1.1e-09 TIGR00229: PAS domain S-box protein" amino acids 256 to 368 (113 residues), 24.6 bits, see alignment E=2.3e-09 PF13426: PAS_9" amino acids 256 to 361 (106 residues), 36 bits, see alignment E=1.8e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 371 to 534 (164 residues), 142.3 bits, see alignment E=1.2e-45 PF00990: GGDEF" amino acids 373 to 529 (157 residues), 152.6 bits, see alignment E=2.1e-48 PF00563: EAL" amino acids 551 to 785 (235 residues), 246.7 bits, see alignment E=5.5e-77

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165M248 at UniProt or InterPro

Protein Sequence (804 amino acids)

>Ac3H11_4154 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) (Acidovorax sp. GW101-3H11)
MRFFKPSSLTAKTLAWVVVASLVAFAAITGVTVWQERALLLQRAHEQAQRSVQQNLPALS
ESLWNFNNAGLRALLSGMVGEGAIVRADILDGERTLMTVSRPGEVPPIDTTWTTPIADPT
HPGAGQPPLGEIRVYESYAALRAQQAETAWRIAIAQLLQIASIAAMLVVIVRWLIMRHLS
ALARAVTGLNPLDHQDRIRLQRRASGAQPDELDALVDALNRFHTERATEAGLRLRAEHAL
RARVQEIEATLGALSDGVLALNGSGEVAYANGAAARLLGMDEPALQGQPWHNLLRLLDEA
SGEPRGEWLEQARLSGKPQRVRGELRIAPAHARAFVAELNAVPLHSPGDVVLLLVLRDIS
EEIDKERQIVFQAFHDPLTGLGNRSKLARDLPQDLARARAAQGRLALLFIDLDNFKDIND
TLGHQVGDLLLRQLALRLQASVMPPAWVTRHGGDEFLVVLPQLGGDEQAIALAQELMNQI
RRPFTLEGYQLHVTPSVGISFFPDHGSTPAELVSRADMGMYAAKKLGRNTYCVFDDRQLQ
ESSRRLNVENGLRTALAQGEFWLAYQPKVDLATGRVAGVEALLRWESQQLGRIPPASFIP
IAEESGLIIDIGDWVLREAIAAARRWRDMLGTEVPVAVNVAAAQFRSPRLLQALRAIAAE
DRDIPRLIQLEVTESALISGLEDVTGKFIALKELGYSIAIDDFGTGYSSLSYLKNLPVDT
LKIDQAFIRDLHRSTQDVTIVSAVVRMGQSLGFAIVAEGVEEARHVQILQGLGCDQGQGY
HFSRPVPEAELIPLLKEGCGTVKA