Protein Info for Ac3H11_3949 in Acidovorax sp. GW101-3H11

Annotation: Outer membrane stress sensor protease DegS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 507 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details TIGR02037: peptidase Do" amino acids 58 to 502 (445 residues), 483.6 bits, see alignment E=2.8e-149 PF00089: Trypsin" amino acids 138 to 282 (145 residues), 63.4 bits, see alignment E=9.9e-21 PF13365: Trypsin_2" amino acids 138 to 271 (134 residues), 132.8 bits, see alignment E=5.9e-42 PF00595: PDZ" amino acids 308 to 367 (60 residues), 37 bits, see alignment E=1.3e-12 amino acids 419 to 493 (75 residues), 35.8 bits, see alignment E=3e-12 PF13180: PDZ_2" amino acids 311 to 401 (91 residues), 56.8 bits, see alignment E=8.2e-19 amino acids 421 to 505 (85 residues), 28.6 bits, see alignment E=5.3e-10 PF17820: PDZ_6" amino acids 337 to 389 (53 residues), 45.9 bits, see alignment 1.4e-15 amino acids 448 to 495 (48 residues), 46.9 bits, see alignment 6.6e-16

Best Hits

KEGG orthology group: K01362, [EC: 3.4.21.-] (inferred from 73% identity to aav:Aave_3965)

Predicted SEED Role

"Outer membrane stress sensor protease DegS" in subsystem Proteolysis in bacteria, ATP-dependent

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LXD3 at UniProt or InterPro

Protein Sequence (507 amino acids)

>Ac3H11_3949 Outer membrane stress sensor protease DegS (Acidovorax sp. GW101-3H11)
MNTTTLTSTPRRLILALVAAGAVGAMGAGLITGHQARALTQPPAIVAQTPAAPGGALPSF
AQITAQNGPAVVNISVTGSTKTAMADDDGEDEGQPTARQGRGPQMDPNDPFYQFFRQFGF
PGGAGPQAQPNVPTHGQGSGFIVSPDGLVLTNAHVVKGASDVTVKLTDRREFRAKVLGAD
PKTDVAVLKIDAKDLPMVRLGSTRDLQVGEWVLAIGSPFGFENSVTAGVVSAKGRSLPDD
SLVPFIQTDVAVNPGNSGGPLFNARGEVVGINSQIYSRSGGYQGLSFSIPIELAAKIKDQ
IVATGKVRHAQLGVAVQEVNQAFAESFNLDKPEGALVASVSKGSPAEKAGLQAGDVIRQV
DGQPIVASGDLPAWVGQAQPGQQAKLSVWRQGKPVELTATLGDASDKAIKQARNDDAVGK
GQLGLSLRPLEREERQEVGVSEGLVIEQARGPAAAAGVQPGDVLLAINGAPAKNIEQVRA
AMAKAGKSVALLIARDGNKIFVPVRLG