Protein Info for Ac3H11_3809 in Acidovorax sp. GW101-3H11

Annotation: tungsten-containing formate dehydrogenase beta subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 635 PF01257: 2Fe-2S_thioredx" amino acids 57 to 188 (132 residues), 81.2 bits, see alignment E=1.4e-26 PF01512: Complex1_51K" amino acids 261 to 421 (161 residues), 129.2 bits, see alignment E=2.6e-41 PF10531: SLBB" amino acids 446 to 495 (50 residues), 30.3 bits, see alignment 6.1e-11 PF10589: NADH_4Fe-4S" amino acids 533 to 609 (77 residues), 78 bits, see alignment E=8.4e-26

Best Hits

KEGG orthology group: K05903, NADH dehydrogenase (quinone) [EC: 1.6.99.5] (inferred from 86% identity to ajs:Ajs_3471)

Predicted SEED Role

"tungsten-containing formate dehydrogenase beta subunit" in subsystem Formate hydrogenase

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.6.99.5

Use Curated BLAST to search for 1.6.99.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LU11 at UniProt or InterPro

Protein Sequence (635 amino acids)

>Ac3H11_3809 tungsten-containing formate dehydrogenase beta subunit (Acidovorax sp. GW101-3H11)
MHLAPEAPPATVVAAVSVNDMRERIRRKSRLKGRQPEDAAMADVAQLLGPRPATGFRRDL
LIEYLHRLNDHFGVLHDRHLVALAKQMNLPMAEVYEVASFYHHFEIVRGDDAQAPRLVLR
VCDSLSCSLAGARELLAALPERLRAAGQGDVQVLAVPCVGRCEQAPVAVVHQCPVPRATV
DTVLEVVESKPKRALARHPQALKAINFDVAALAEKSIPTSLREVSPAHTDLATYRAHGGY
QTAAALVNGEMDAEAVLAAMEDSGLRGLGGAGFPAGRKWRIVRDQPAPRLMAVNIDEGEP
GTFKDRTYLERDPHRFLEGVLIAAQVVGTEAIYIYLRDEYHGCRVLLQQALDDLRAEPPC
PLPHIELRRGAGAYICGEESAMIESIEGKRGEPRMRPPYIAQVGLFGRPTLEHNFETLYW
VRDIVERGPQWFASFGRHGRKGLRSFSVSGRVKHPGVKLAPAGITVQELIDEYCGGLLDG
HQLYAYLPGGASGGILPASLNQIPLDFDTLQPYGCFIGSAAVIVLSQHDRARDAALNVMR
FFEHESCGQCTPCRVGTAKAATLMEAPQWDGDLLDDLAQVMGDASICGLGQAAPNPIRCI
HKYFPHEVGEGSWPGDQPKPRNSPLAEQLPAGGKP