Protein Info for Ac3H11_3808 in Acidovorax sp. GW101-3H11

Annotation: tungsten-containing formate dehydrogenase alpha subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 961 PF13510: Fer2_4" amino acids 10 to 81 (72 residues), 67.4 bits, see alignment 4.3e-22 PF13187: Fer4_9" amino acids 185 to 243 (59 residues), 27.6 bits, see alignment 1.1e-09 PF12838: Fer4_7" amino acids 185 to 243 (59 residues), 32.9 bits, see alignment 3.3e-11 PF00037: Fer4" amino acids 226 to 244 (19 residues), 26.2 bits, see alignment (E = 2.3e-09) PF04879: Molybdop_Fe4S4" amino acids 258 to 308 (51 residues), 60.1 bits, see alignment 7.5e-20 TIGR01591: formate dehydrogenase, alpha subunit" amino acids 262 to 953 (692 residues), 696.1 bits, see alignment E=2e-213 PF00384: Molybdopterin" amino acids 312 to 753 (442 residues), 238 bits, see alignment E=7.5e-74 PF01568: Molydop_binding" amino acids 844 to 950 (107 residues), 93.4 bits, see alignment E=4.2e-30

Best Hits

KEGG orthology group: K00123, formate dehydrogenase, alpha subunit [EC: 1.2.1.2] (inferred from 82% identity to adk:Alide2_1046)

Predicted SEED Role

"tungsten-containing formate dehydrogenase alpha subunit" in subsystem Formate hydrogenase

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LTZ7 at UniProt or InterPro

Protein Sequence (961 amino acids)

>Ac3H11_3808 tungsten-containing formate dehydrogenase alpha subunit (Acidovorax sp. GW101-3H11)
MSAAHDTPGVAFELDGQPVTAHPGETILKAAQRHGVEIPHLCYTDGLRPDGNCRACVVEI
AGERTLAPSCCRAPTEGMKVLATSPRARKSQQMVVEMLLSDMPDQGYRWNDGGANTPELI
AENIDPSGGKGLFDSKNSGTIGQHGELSAWADRLGVTVRPALQALRREQPAPDLSHPAMA
VNLDACIQCNRCVRACREEQVNDVIGYALRGAESKIVFDLDDPMAESTCVACGECVQACP
TGALSPKTHIGSQKVDRQVDSVCPFCGVGCLITYNVRDEKIISVEGRDGPANQGRLCVKG
RFGFDYAHHPDRLTVPLIRKPGVPKEVRPYGADWRSTFREATWDEALDLAAGQLKGLRDT
HGRKALAGFGSAKGSNEEAYLFQKLVRTGFGSNNVDHCTRLCHASSVAALLEGVGSGAVS
NPVNDVEHAGLIFVIGSNPTANHPVAATWMKNAAKRGAKIVLADPRVTDIGRHAWRTLQF
KADTDVAMLNALIHTVIDEGLVDEAFIRDRTTDFEALKANVLGCSPEAMAPVCGIPAEAL
REVARAFATSKASMILWGMGVSQHVHGTDNARCLIALCAVTGQIGKPGSGLHPLRGQNNV
QGASDAGLIPMMFPNYQRVDNAGAHAWFEDFWGTQLDEAPGYTVVEIMHKALADDSDPHK
VRGMYIMGENPAMSDPDLNHARHALASLSHLVVQDIFLTETAWLADVVLPASAWPEKTGT
ASNTDRMVQMGRRALNPPGDARLDLWIIQQLARRMGLDWNYEGEESGVAAVYDEMRQAMH
ASIEGITWDRLERDSSVTYPCLTADDPGQPIVFTQQFPTPTGRLKLVPASVIPAAEKPDA
DYPLVLITGRQLEHWHTGSMTRRSTVLDAIEPMATASLHGDELARLGVEPGALVGIRSRR
GMLQVRVRRDDGTPRGTVFMPFAYVEAAANLLTNAALDPFGKIPEFKYCAVAVEVLEGAA
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