Protein Info for Ac3H11_318 in Acidovorax sp. GW101-3H11

Annotation: Multidrug resistance transporter, Bcr/CflA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 414 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 56 to 77 (22 residues), see Phobius details amino acids 89 to 108 (20 residues), see Phobius details amino acids 114 to 135 (22 residues), see Phobius details amino acids 147 to 169 (23 residues), see Phobius details amino acids 175 to 195 (21 residues), see Phobius details amino acids 227 to 252 (26 residues), see Phobius details amino acids 263 to 281 (19 residues), see Phobius details amino acids 293 to 314 (22 residues), see Phobius details amino acids 320 to 339 (20 residues), see Phobius details amino acids 351 to 374 (24 residues), see Phobius details amino acids 382 to 404 (23 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 23 to 400 (378 residues), 234 bits, see alignment E=2e-73 PF07690: MFS_1" amino acids 29 to 369 (341 residues), 152.4 bits, see alignment E=1.6e-48 PF00083: Sugar_tr" amino acids 66 to 136 (71 residues), 26.4 bits, see alignment E=3.3e-10

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 82% identity to vei:Veis_4226)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165JNH8 at UniProt or InterPro

Protein Sequence (414 amino acids)

>Ac3H11_318 Multidrug resistance transporter, Bcr/CflA family (Acidovorax sp. GW101-3H11)
MSAPSATALPAAPAPVSIHPGLAILVLALLLSIQPVTTDLYLPALPALTRSLGAPLSAAQ
LTLSGLLLAFGCSQMVWGPLSDRFGRRPVLLAGLSIYTVASVGSALAPSMALLIVWRIAQ
GAAMGAVVMCARAIVRDLYTPLEGARAMSKALTGLGIVACICAPLGGLLSEWLGWRAALS
ALTVYALVTLALVALRMPETLAQRNPQALQPRALAGTWMHVLKSPTFWAFSLQTTATYGG
LFTFLAASSFVYIDVLGLSRTQFGWTMASACAAYLGGTFLCRRLLARHGLQRTVAIAGGL
SVAGGTLMALVAWMGWHHPWALLLPFYLFMLGHGIHQPCGQSGAVGPFPQAAGVASALNG
FMMMLAAFAIGGWLGQRLDGTVWPLVNGIWFWSVVLALISWTLVQKFGAARDRA