Protein Info for Ac3H11_2962 in Acidovorax sp. GW101-3H11
Annotation: Nicotinate phosphoribosyltransferase (EC 2.4.2.11)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 69% identical to PNCB_HERAR: Nicotinate phosphoribosyltransferase (pncB) from Herminiimonas arsenicoxydans
KEGG orthology group: K00763, nicotinate phosphoribosyltransferase [EC: 2.4.2.11] (inferred from 82% identity to aav:Aave_0976)Predicted SEED Role
"Nicotinate phosphoribosyltransferase (EC 2.4.2.11)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation or Redox-dependent regulation of nucleus processes (EC 2.4.2.11)
MetaCyc Pathways
- NAD salvage pathway I (PNC VI cycle) (5/7 steps found)
- NAD salvage pathway V (PNC V cycle) (3/5 steps found)
- superpathway of NAD biosynthesis in eukaryotes (9/14 steps found)
- NAD salvage (plants) (5/11 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Nicotinate and nicotinamide metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.11
Use Curated BLAST to search for 2.4.2.11
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A165L3L1 at UniProt or InterPro
Protein Sequence (402 amino acids)
>Ac3H11_2962 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) (Acidovorax sp. GW101-3H11) MHPVITSLLDTDLYKFTMWQALLHRHPQTQSEYRFVCRNQPQYPLAELLPEVNAALDHLC SLRFTKGELDYLAGLRFIKSDFIDFLRIFQFQRSFIEARAEGDTLTIVARGPQVHVMGFE IFVLAIVNELYFRRFNATAALASGRERLAVKVHQLQDLAQQATLRHPFELFDFGLRRRYS GAWQREVVQTFATQAPQWFKGTSNVLLARDLGLVPIGTMAHEYLQSYQALGVRLRDFQKA ALEDWVQEYRGDLGIALTDTVGMDAFLADFDLYFAKLFDGLRHDSGDPVAWGEKALAHYA KLRIDAHTKRLVFSDGLTLTKALALYRHFGDRTQLGFGIGTHLTNDMGNPEVTPEMKPLN IVMKLTRANGQAVAKLSDTPGKTLCDDETYLAYLRQVFNVKD