Protein Info for Ac3H11_2219 in Acidovorax sp. GW101-3H11

Annotation: Type I secretion outer membrane protein, TolC precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 444 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details TIGR01844: type I secretion outer membrane protein, TolC family" amino acids 25 to 442 (418 residues), 297 bits, see alignment E=1.2e-92 PF02321: OEP" amino acids 29 to 215 (187 residues), 89.3 bits, see alignment E=1.4e-29 amino acids 239 to 428 (190 residues), 106.2 bits, see alignment E=9.4e-35

Best Hits

KEGG orthology group: K12340, outer membrane channel protein TolC (inferred from 81% identity to vei:Veis_2352)

Predicted SEED Role

"Type I secretion outer membrane protein, TolC precursor" in subsystem Multidrug Resistance Efflux Pumps or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168F730 at UniProt or InterPro

Protein Sequence (444 amino acids)

>Ac3H11_2219 Type I secretion outer membrane protein, TolC precursor (Acidovorax sp. GW101-3H11)
MTPFRPLSLSLLSLALGAALTAPAQAQSLLELVESARTYDTAWQSARAQLDAAGRKADQA
RAGLLPSAALTGGLTRSNVELSRPKIENTGTAQTVGINASQPLYRPANRINLEQGQRGVD
VAQAQLDGATQDLLVRVSQAYFDVLAAQDTLTFVQAQKAAVSEQLASAKRNFEVGTTTVT
DSREAQARYDLVIAQEIAAENDLRVKRLALDQLVGITGTQPRPLALPLQLPSVQPANVAT
WVDTARDQQPGVRQAAIALDIARLETKKAETGHLPTVDLQAGYNVTRNLNGTISAPGVTN
RSNAASVGVALNLPLFAGFAVQNRVKETLALEEKATADLETTRRNVAQATRAAFFGVQSG
QGQVQALEAAEASSQSALDANKLGYQVGVRINIDVLNAQSQLFQTKRDLAQARYNVLLGT
LKLRQAAGTLTQQDVEAINALLVK