Protein Info for Ac3H11_2083 in Acidovorax sp. GW101-3H11

Annotation: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) @ 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01182: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
  • amino acids 8 to 203 (196 residues), 250 bits, E=6.6e-79
• PF01081: Aldolase
  • amino acids 8 to 198 (191 residues), 248.1 bits, E=2.5e-78

Best Hits

Swiss-Prot: 54% identical to ALKH_ECOL6: KHG/KDPG aldolase (eda) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K01625, 2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC: 4.1.2.14 4.1.3.16] (inferred from 90% identity to vei:Veis_2569)

MetaCyc: 52% identical to 2-dehydro-3-deoxy-phosphogluconate aldolase (Pseudoalteromonas atlantica T6c)
2-dehydro-3-deoxy-phosphogluconate aldolase. [EC: 4.1.2.14, 4.1.2.55]

Predicted SEED Role

"4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) @ 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)" (EC 4.1.2.14, EC 4.1.3.16)

MetaCyc Pathways

• superpathway of glycolysis and the Entner-Doudoroff pathway (16/17 steps found)
• Entner-Doudoroff pathway I (9/9 steps found)
• D-galactonate degradation (3/3 steps found)
• Entner-Doudoroff shunt (2/2 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (6/9 steps found)
• trans-4-hydroxy-L-proline degradation I (3/5 steps found)
• D-fructuronate degradation (2/4 steps found)
• D-glucosaminate degradation (1/3 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (2/5 steps found)
• D-galacturonate degradation I (2/5 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (3/7 steps found)
• L-glucose degradation (3/7 steps found)
• superpathway of β-D-glucuronosides degradation (3/7 steps found)
• superpathway of hexuronide and hexuronate degradation (3/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (12/31 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glyoxylate and dicarboxylate metabolism
• Pentose and glucuronate interconversions
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.14 or 4.1.2.55 or 4.1.3.16

Sequence Analysis Tools

See A0A165KQH1 at UniProt or InterPro

Protein Sequence (209 amino acids)

>Ac3H11_2083 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) @ 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) (Acidovorax sp. GW101-3H11)
MNPLDIASHGPVIPVIVIDRVEDALPLAEALLAGGVKVLEVTLRTAAGLPAIEAIARHLP
EAVVGVGTVLNADDARRASEAGARFAVSPGYTSEVGSACKGLNLPLLPGVATSSEIMTAL
ADGFSFLKLFPAEAVGGIPLLKSWASPFGQVSFCPTGGITNATAPNYLALPNVRCVGGSW
LTPTDAVRAGDWARITELARATQALRNAG