Protein Info for Ac3H11_1909 in Acidovorax sp. GW101-3H11

Annotation: ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 159 to 182 (24 residues), see Phobius details PF08521: 2CSK_N" amino acids 20 to 159 (140 residues), 68.4 bits, see alignment E=1e-22 PF00512: HisKA" amino acids 237 to 262 (26 residues), 27 bits, see alignment (E = 5.7e-10) PF02518: HATPase_c" amino acids 378 to 486 (109 residues), 72.3 bits, see alignment E=6.5e-24

Best Hits

KEGG orthology group: K07649, two-component system, OmpR family, sensor histidine kinase TctE [EC: 2.7.13.3] (inferred from 62% identity to rfr:Rfer_3522)

Predicted SEED Role

"ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165KL58 at UniProt or InterPro

Protein Sequence (486 amino acids)

>Ac3H11_1909 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal (Acidovorax sp. GW101-3H11)
LRAMTSDLRTRLLLMLVLPLCALALVGVWLDYRSADEAAVQHDQRLVRLLPALADSVLAP
PIRDNASPLLLLAPPIEEFLRQNVGFSAYSVRDTSGRLLLGDSWVHGAVPTTQAPEFHSV
EFGGVTYRVAVQRGRTGAGELVVALADGSDPRQKWAQQLLLRVLLPNLVLLLAAGFAIHW
AVRQAFKPLVGLAEAVERRSPRDLSPIDEAASPDEVRPLVHSLNRLFALVNAQAEGQRRF
VADAAHQLRTPLAGLQAQVEAWAMMAKAAAPPQVSFPDFDRKMPFAREDRAQGAIVLGVD
QIEKLRNATRRTSQLAHQLLALSRADARSLDAQPPQRVDLKDLCESLLENFLDAATGKGL
DLGLDVQLVHVTGHGWLLRELLSNLVDNAIKYTPPGGVVTIRCGLRQGRSGPPRAYVEVE
DDGPGVPEAERTRVLQRFYRVPGAGGEGTGLGLAIADEIARVHRAALTLGAGPQGRGLLV
TVVFPL